Focusing ion funnel-assisted ambient electrospray enables high-density and uniform deposition of non-spherical gold nanoparticles for highly sensitive surface-enhanced Raman scattering.
Focusing ion funnel-assisted ambient electrospray enables high-density and uniform deposition of non-spherical gold nanoparticles for highly sensitive surface-enhanced Raman scattering.
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聚焦离子漏斗辅助环境电喷雾能够实现非球形金纳米颗粒的高密度和均匀沉积，从而实现高灵敏度的表面增强拉曼散射。
DOI：
10.1039/d3an01021j
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Akbali B
中科院分区：
文献类型：
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作者：
Akbali B
表面增强拉曼散射（Sers）是一种检测痕量分析物的有效技术。然而，Sers基底的性能取决于许多变量，包括增强因子、形态、一致性以及与目标分析物的相互作用。在这项研究中，我们调查，第一次，使用电喷雾沉积（ESD）结合一种新的环境聚焦直流离子漏斗存款高密度的金纳米粒子（AuNPs），以产生大面积，均匀的高灵敏度的Sers分析基板。我们发现环境离子聚焦与ESD的组合促进了非球形NP的高密度和完整沉积。这也使我们能够利用多分散胶体溶液的金纳米粒子（由纳米球和纳米棒），证实了有限差分时域（FDTD）模拟。我们的Sers基底对模型分析物分子，即4-氨基苯硫酚（4-ATP）和罗丹明6 G（R6 G）表现出优异的捕获能力，检测限在10−11 M范围内，在大面积（10500 × 500 μm2）上的相对标准偏差<6%。此外，我们使用R6 G探针分子评估了我们Sers底物的定量性能。结果表明，在宽浓度范围（10−4 M至10−10 M）内具有良好的线性（R2 > 0.99），检测限为80 pM。
Surface-enhanced Raman scattering (SERS) is a powerful technique for detecting trace amounts of analytes. However, the performance of SERS substrates depends on many variables including the enhancement factor, morphology, consistency, and interaction with target analytes. In this study, we investigated, for the first time, the use of electrospray deposition (ESD) combined with a novel ambient focusing DC ion funnel to deposit a high density of gold nanoparticles (AuNPs) to generate large-area, uniform substrates for highly sensitive SERS analysis. We found that the combination of ambient ion focusing with ESD facilitated high-density and intact deposition of non-spherical NPs. This also allowed us to take advantage of a polydisperse colloidal solution of AuNPs (consisting of nanospheres and nanorods), as confirmed by finite-difference time domain (FDTD) simulations. Our SERS substrate exhibited excellent capture capacity for model analyte molecules, namely 4-aminothiophenol (4-ATP) and Rhodamine 6G (R6G), with detection limits in the region of 10−11 M and a relative standard deviation of <6% over a large area (∼500 × 500 μm2). Additionally, we assessed the quantitative performance of our SERS substrate using the R6G probe molecule. The results demonstrated excellent linearity (R2 > 0.99) over a wide concentration range (10−4 M to 10−10 M) with a detection limit of 80 pM.