RdRp mutations are associated with SARS-CoV-2 genome evolution
RdRp mutations are associated with SARS-CoV-2 genome evolution
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RdRp 突变与 SARS-CoV-2 基因组进化相关
DOI：
10.1101/2020.05.20.104885
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发表时间：
2020
期刊：
影响因子：
2.7
通讯作者：
Y. Oktay
中科院分区：
文献类型：
--
作者：
Doğa Eskier;G. Karakülah;A. Suner;Y. Oktay
COVID-19由新型SARS-CoV-2病毒引起，于2019年底在中国开始，并很快成为全球大流行病。在积累的数千个病毒基因组序列的帮助下，随着时间的推移，随着病毒在世界各地的传播，追踪病毒基因组的进化已经成为可能。仍然需要回答的一个重要问题是，是否有任何常见的突变影响病毒的特性，从而影响疾病的特征。因此，我们试图了解RNA依赖性RNA聚合酶（RdRp）突变，特别是常见的14408 C>T突变对突变率和病毒传播的影响。通过关注缓慢进化的M或E基因中的突变，我们的目标是最大限度地减少选择压力的影响。我们的研究结果表明，14408 C>T突变增加了突变率，而第三常见的RdRp突变15324 C>T则具有相反的效果。14408 C>T突变可能导致其在欧洲和其他地方的共突变占主导地位。
COVID-19, caused by the novel SARS-CoV-2 virus, started in China in late 2019, and soon became a global pandemic. With the help of thousands of viral genome sequences that have been accumulating, it has become possible to track the evolution of viral genome over time as it spread across the world. An important question that still needs to be answered is whether any of the common mutations affect the viral properties, and therefore the disease characteristics. Therefore, we sought to understand the effects of mutations in RNA-dependent RNA polymerase (RdRp), particularly the common 14408C>T mutation, on mutation rate and viral spread. By focusing on mutations in the slowly evolving M or E genes, we aimed to minimize the effects of selective pressure. Our results indicate that 14408C>T mutation increases the mutation rate, while the third-most common RdRp mutation, 15324C>T, has the opposite effect. It is possible that 14408C>T mutation may have contributed to the dominance of its co-mutations in Europe and elsewhere.