Desipramine treatment reduces the long-term behavioural and neurochemical sequelae of early-life maternal separation
Desipramine treatment reduces the long-term behavioural and neurochemical sequelae of early-life maternal separation
复制标题
DOI：
10.1017/s1461145703003729
复制
发表时间：
2003-12-01
影响因子：
4.8
通讯作者：
Young, LT
中科院分区：
文献类型：
--
作者：
MacQueen, GM;Ramakrishnan, K;Young, LT
灵长类动物和啮齿类动物的母体分离模型表明，出生后反复将幼崽与母亲分离会导致与抑郁症相关的神经激素系统发生长期变化。然而，迄今为止，尚不清楚经历产后母亲分离的啮齿动物是否在成年后表现出抑郁症的特定行为或生化特征，以及这些变化是否需要通过抗抑郁药物治疗来预防。我们在这里报告说，母亲分开的小鼠表现出显着较短的游泳时间的强迫游泳测试和显着较低水平的脑源性神经营养因子在齿状回和海马CA3区相比，对照组小鼠在成年期进行评估。这些差异在母体分离后接受抗抑郁药地昔帕明长期治疗的母体分离小鼠中均不明显。这些结果表明，干预后的早期压力可能会消除长期的脆弱性，行为和生化功能障碍，发生后，这种早期的慢性压力。
Primate and rodent models of maternal separation have shown that repeated postnatal separation of young from the mother results in long-term changes to neurohormonal systems relevant to depression. To date, however, it remains unclear whether rodents that experience Postnatal maternal separation display specific behavioural or biochemical features of depression in adulthood and whether these changes call be prevented by treatment with antidepressant drugs. We report here that maternally separated mice showed significantly shorter swim times on the forced swim test and significantly lower levels of brain derived neurotrophic factor in dentate gyrus and CA3 regions of the hippocampus compared to control mice when assessed in adulthood. Neither of these differences was apparent in maternally separated mice that received chronic treatment with the antidepressant desipramine after maternal separation. These results suggest that intervention following early stress may eliminate the long-term vulnerability to behavioural and biochemical dysfunction that occurs following this early chronic stress.