Exploring the role of context-dependent hippocampal activity in spatial alternation behavior
Exploring the role of context-dependent hippocampal activity in spatial alternation behavior
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DOI：
10.1002/hipo.20301
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发表时间：
2007-01-01
期刊：
影响因子：
3.5
通讯作者：
Wood, Emma R.
中科院分区：
文献类型：
--
作者：
Ainge, James A.;van der Meer, Matthijs A. A.;Wood, Emma R.
在连续的 T 迷宫空间交替任务中，当大鼠进行左转和右转试验时，CA1 将细胞在迷宫的茎上进行不同的放电（Wood 等人（2000）Neuron 27：623633）。这种依赖于环境的海马活动提供了一种潜在机制，动物可以通过该机制解决交替任务，因为它提供了可以启动适当目标选择的线索。本研究的目的是检查情境依赖性海马活动与空间交替行为之间的关系。我们报告说，海马体完全损伤的大鼠学习并执行空间交替任务，如果试验之间没有延迟，则可以进行控制，这表明观察到的上下文依赖的海马活动不会介导该任务中的交替行为。然而，当延迟 2 或 10 秒时，受损大鼠会受到显着损害。记录实验表明，上下文相关的海马活动发生在任务的延迟和无延迟版本中，但在延迟版本中，它发生在延迟期间，而不是在迷宫的茎上。这些数据与上下文相关的海马活动在延迟空间交替中的作用一致，但表明根据特定的任务需求和记忆负荷，该活动可能是由不同的机制和/或在不同的大脑结构中产生的。 (c) 2007 年 Wiley-Liss, Inc.
In a continuous T-maze spatial alternation task, CA1 place cells fire differentially on the stem of the maze as rats are performing left- and right-turn trials (Wood et al. (2000) Neuron 27:623633). This context-dependent hippocampal activity provides a potential mechanism by which animals could solve the alternation task, as it provides a cue that could prime the appropriate goal choice. The aim of this study was to examine the relationship between context-dependent hippocampal activity and spatial alternation behavior. We report that rats with complete lesions of the hippocampus learn and perform the spatial alternation task as well as controls if there is no delay between trials, suggesting that the observed context-dependent hippocampal activity does not mediate alternation behavior in this task. However lesioned rats are significantly impaired when delays of 2 or 10 s are interposed. Recording experiments reveal that context-dependent hippocampal activity occurs in both the delay and no-delay versions of the task, but that in the delay version it occurs during the delay period, and not on the stem of the maze. These data are consistent with a role for context-dependent hippocampal activity in delayed spatial alternation, but suggest that, according to specific task demands and memory load, the activity may be generated by different mechanisms and/or in different brain structures. (c) 2007 Wiley-Liss, Inc.