Postoperative recurrence with right cervical lymph node metastasis in hepatocellular carcinoma: a case report.
Postoperative recurrence with right cervical lymph node metastasis in hepatocellular carcinoma: a case report.
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DOI：
10.1186/s40792-021-01352-y
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发表时间：
2021-12-17
影响因子：
0.8
通讯作者：
Ohtsuka T
中科院分区：
文献类型：
--
作者：
Tanoue K;Kawasaki Y;Yamasaki Y;Iino S;Sakoda M;Mataki Y;Idichi T;Kita Y;Hozaka Y;Nakajo A;Arigami T;Kurahara H;Ohtsuka T
肝细胞癌（HCC）颈部淋巴结转移极为罕见，其临床病程特点是病情进展迅速。因此，在术后长时间监测后，尚无转移性颈部淋巴结复发的报告。患者是一名 63 岁男性，因右上叶肝癌接受了右肝切除术。切除三年后，膈下、上纵隔和右颈淋巴结检测到转移性淋巴结复发。患者接受了颈部淋巴结切除活检，随后进行了分子靶向治疗和放射治疗。仑伐替尼缩小了所有转移淋巴结的大小，患者在检测到复发后存活了 43 个月的相对较长时期。右上叶肝细胞癌切除后，可能会在不寻常部位（包括颈部）出现转移性淋巴结复发，乐伐替尼可能对这些复发有效。
Hepatocellular carcinoma (HCC) patients with metastases to the cervical lymph nodes are extremely rare, and its clinical course is characterized by rapidly progressive disease. Hence, there have been no reports of metastatic cervical lymph node recurrence indicated after a long postoperative surveillance period. The patient was a 63-year-old male who underwent right hepatectomy for HCC of the right upper lobe. Three years after resection, metastatic lymph node recurrence was detected in the subdiaphragm, superior mediastinum, and right cervical lymph nodes. The patient underwent excisional biopsy of the cervical lymph node, followed by molecular-targeted therapy and radiation therapy. Lenvatinib reduced the size of all metastatic lymph nodes and the patient survived for a relatively long period of 43 months after the recurrence was detected. After resection of HCC in the right upper lobe, there is the possibility of metastatic lymph node recurrence in unusual sites, including the cervical region, and lenvatinib may be effective in those recurrences.