Combining Spatial and Temporal Information to Explore Function-Guide Action of Acupuncture Using fMRI
Combining Spatial and Temporal Information to Explore Function-Guide Action of Acupuncture Using fMRI
复制标题
结合空间和时间信息利用功能磁共振成像探索针灸的功能引导作用
DOI：
10.1002/jmri.21805
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发表时间：
2009-07-01
影响因子：
4.4
通讯作者：
Liu, Yijun
中科院分区：
文献类型：
--
作者：
Liu, Peng;Qin, Wei;Liu, Yijun
目的：研究GB37和KI8调制的脑反应模式。材料和方法：采用非重复事件相关功能磁共振成像设计(WASH)，对28名受试者进行电针刺激左腿GB37或KI8的实验。采用离散余弦变换和功能连接方法检测EAS前后这两个穴位的相关差异。结果：EAS在两个穴位的空间格局不同，重叠的脑区主要位于扣带后皮质(PCC)和楔前叶(PC)。利用重叠的PCC/PC作为感兴趣区域，从时间模式中检测到默认模式网络中的两种相反的调制模式。结论：GB37和KI8对穴位持续效应的调制具有不同的时空模式。我们认为这些发现可能归因于特定穴位的功能特异性。更有甚者。我们目前的结果反映了对未来针灸研究的重大方法论贡献。
Purpose: To investigated the brain response patterns of modulation of GB37 (Guangming) and KI8 (Jiaoxin).Materials and Methods: An experiment using nonrepeated event-related fMRI design, wash, carried out on 28 subjects with electroacupuncture stimulation (EAS) at GB37 or KI8 on the left-leg. The discrete cosine transform and functional connectivity methods were adopted to detect the differences related with these two acupoints before and after the EAS.Results: Spatial patterns were distinct for EAS at the two acupoints, and the overlapping brain regions were mainly located in the posterior cingulate cortex (PCC) and precuneus (pC). Two opposite patterns of modulation in the default mode network were detected from the temporal patterns with the overlapping PCC/pC as the region of interest. Furthermore, the specific responses of sustained effects at these acupoints were also identified.Conclusion: Spatial and temporal patterns of the sustained effect modulation of GB37 and KI8 were distinct. We suggest these findings may attribute to the functional specificity of a certain acupoint. Moreover. our current results reflect a significant methodological contribution to future acupuncture studies.