The Origins of Nucleotides

The Origins of Nucleotides
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DOI:
10.1055/s-0030-1261177
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发表时间:
2011-09-01
期刊:
影响因子:
2
通讯作者:
Szostak, Jack W.
Szostak, Jack W.
中科院分区:
化学4区
文献类型:
--
作者:
Powner, Matthew W.;Sutherland, John D.;Szostak, Jack W.

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The origins of life represent one of the most fundamental chemical questions being addressed by modern science. One of the longstanding mysteries of this field is what series of chemical reactions could lead to the molecular biologists dream; a pool of homochiral nucleotides? Here we summarize those results we consider to be historically important and outline our recently published research aimed at understanding the chemoselective origins of the canonical ribonucleotides.