Lactic acid as an invaluable green solvent for ultrasound-assisted scalable synthesis of pyrrole derivatives.
Lactic acid as an invaluable green solvent for ultrasound-assisted scalable synthesis of pyrrole derivatives.
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DOI：
10.1016/j.ultsonch.2015.01.002
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发表时间：
2015-09
影响因子：
8.4
通讯作者：
Shi‐Fan Wang;Chaowen Guo;Kexu Cui;Yan-Ting Zhu;J. Ding;Xin Zou;Yi-hang Li
中科院分区：
文献类型：
--
作者：
Shi‐Fan Wang;Chaowen Guo;Kexu Cui;Yan-Ting Zhu;J. Ding;Xin Zou;Yi-hang Li
乳酸已被用作生物基绿色溶剂来研究超声辅助放大合成。我们在这里首次报告了在超声波辐射下在乳酸溶剂中合成吡咯衍生物的新颖且可扩展的工艺。在超声辐射下，在乳酸溶剂中合成了18种吡咯衍生物，并通过1H NMR、IR、ESI MS进行了表征。结果表明，在超声波辐射下，乳酸溶剂可以克服放大挑战，并表现出许多优点，例如生物基来源、更短的反应时间、更低的挥发性、更高的产率以及易于分离产物。
Lactic acid has been used as a bio-based green solvent to study the ultrasound-assisted scale-up synthesis. We report here, for the first time, on the novel and scalable process for synthesis of pyrrole derivatives in lactic acid solvent under ultrasonic radiation. Eighteen pyrrole derivatives have been synthesized in lactic acid solvent under ultrasonic radiation and characterized by1H NMR, IR, ESI MS. The results show, under ultrasonic radiation, lactic acid solvent can overcome the scale-up challenges and exhibited many advantages, such as bio-based origin, shorter reaction time, lower volatility, higher yields, and ease of isolating the products.