Influence of psychological factors on risk of temporomandibular disorders
Influence of psychological factors on risk of temporomandibular disorders
复制标题
DOI：
10.1177/154405910708601119
复制
发表时间：
2007-11-01
影响因子：
7.6
通讯作者：
Maixner, W.
中科院分区：
文献类型：
--
作者：
Slade, G. D.;Diatchenko, L.;Maixner, W.
心理特征可能是颞下颌关节紊乱病（TMD）的原因或后果。我们假设与疼痛敏感性相关的心理特征会影响首次发作TMD的风险，但这种影响可能归因于编码儿茶酚-O-甲基转移酶（COMT）的基因变异。我们对1834岁的健康女性志愿者进行了一项前瞻性队列研究。在基线时，参与者进行了基因分型，他们完成了心理问卷调查，并进行了定量感觉测试，以确定疼痛敏感性。我们对171名参与者进行了长达三年的随访，其中8.8%被诊断为首发TMD。抑郁、压力感受和情绪与疼痛敏感性相关，可预测TMD风险增加2- 3倍（P < 0.05）。然而，在调整COMT单倍型后，由于心理因素导致的TMD风险增加的幅度保持不变。与疼痛敏感性相关的心理因素独立于COMT单倍型对TMD风险的影响而影响TMD风险。
Psychological characteristics potentially may be a cause or consequence of temporomandibular disorder (TMD). We hypothesized that psychological characteristics associated with pain sensitivity would influence risk of first-onset TMD, but the effect could be attributed to variation in the gene encoding catechol-O-methyltransferase (COMT). We undertook a prospective cohort study of healthy female volunteers aged 1834 yrs. At baseline, participants were genotyped, they completed psychological questionnaires, and underwent quantitative sensory testing to determine pain sensitivity. We followed 171 participants for up to three years, and 8.8% of them were diagnosed with first-onset TMD. Depression, perceived stress, and mood were associated with pain sensitivity and were predictive of 2- to 3-fold increases in risk of TMD (P < 0.05). However, the magnitude of increased TMD risk due to psychological factors remained unchanged after adjustment for the COMT haplotype. Psychological factors linked to pain sensitivity influenced TMD risk independently of the effects of the COMT haplotype on TMD risk.