LOCAL ADAPTATION AND THE EVOLUTION OF CHROMOSOME FUSIONS
LOCAL ADAPTATION AND THE EVOLUTION OF CHROMOSOME FUSIONS
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DOI：
10.1111/evo.12481
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发表时间：
2014-10-01
期刊：
影响因子：
3.3
通讯作者：
Kirkpatrick, Mark
中科院分区：
文献类型：
--
作者：
Guerrero, Rafael F.;Kirkpatrick, Mark
我们使用群体遗传学的前向模型和合并模型来研究染色体融合，这种融合减少了两个局部适应基因座之间的重组。在大陆-岛屿模型下，当融合导致局部适应的等位基因之间的重组少于它们的选择优势时，融合就会传播并达到多态平衡。相反，双模模型中的融合总是传播的；它是否达到多态平衡或变得固定取决于融合的纯合子和杂合子的相对重组率。围绕融合多态的中性分歧显著增加，在融合点和局部适应的基因座上出现峰值。局部适应可以解释许多染色体融合的进化，这是自然界中最常见的一些染色体重排。
We use forward and coalescent models of population genetics to study chromosome fusions that reduce the recombination between two locally adapted loci. Under a continent-island model, a fusion spreads and reaches a polymorphic equilibrium when it causes recombination between locally adapted alleles to be less than their selective advantage. In contrast, fusions in a two-deme model always spread; whether it reaches a polymorphic equilibrium or becomes fixed depends on the relative recombination rates of fused homozygotes and heterozygotes. Neutral divergence around fusion polymorphisms is markedly increased, showing peaks at the point of fusion and at the locally adapted loci. Local adaptation could explain the evolution of many of chromosome fusions, which are some of the most common chromosome rearrangements in nature.