Production of tumor necrosis factor alpha, interleukin-1 alpha, and interleukin-6 during murine coccidioidomycosis.
Production of tumor necrosis factor alpha, interleukin-1 alpha, and interleukin-6 during murine coccidioidomycosis.
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小鼠球孢子菌病期间肿瘤坏死因子 α、白细胞介素 1 α 和白细胞介素 6 的产生。
DOI：
10.1128/iai.63.10.4178-4180.1995
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发表时间：
1995
影响因子：
3.1
通讯作者：
Magee,DM
中科院分区：
文献类型：
--
作者：
Cox,RA;Magee,DM
在感染粗球孢子菌的小鼠中诱导促炎细胞因子肿瘤坏死因子α（TNF-α）、白细胞介素-1 α（IL-1 α）和白细胞介素-6（IL-6）。分析了两种对C.从感染后第6天到第15天，DBA/2小鼠（抗性品系）肺中IL-6水平高于BALB/c小鼠（敏感品系）。来自两种小鼠品系的脾细胞在体外分泌TNF-α、IL-1 α和IL-6，以响应用杀死的小球刺激，但不同之处在于来自抗性品系的脾细胞在肺激发后早期产生增加水平的这些细胞因子，并且在整个疾病过程中产生增加水平的这些细胞因子。
The proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin-1 alpha (IL-1 alpha), and interleukin-6 (IL-6) were induced in mice infected with Coccidioides immitis. Analyses of the cytokine profiles of two inbred mouse strains which differ in their susceptibility to pulmonary challenge with C. immitis revealed higher levels of IL-6 in lungs from DBA/2 mice (resistant strain) than in those from BALB/c mice (susceptible strain) beginning at day 6 and continuing through day 15 postinfection. Spleen cells from both mouse strains secreted TNF-alpha, IL-1 alpha, and IL-6 in vitro in response to stimulation with killed spherules but differed in that spleen cells from the resistant strain produced increased levels of these cytokines earlier after pulmonary challenge and at increased levels throughout the course of the disease.