Tumor-induced neovascularization in the mouse eye.
Tumor-induced neovascularization in the mouse eye.
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DOI：
10.1093/jnci/69.3.699
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发表时间：
1982-09
期刊：
影响因子：
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通讯作者：
V. Muthukkaruppan;L. Kubai;R. Auerbach
中科院分区：
文献类型：
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作者：
V. Muthukkaruppan;L. Kubai;R. Auerbach
植入小鼠角膜的肿瘤碎片诱导新生血管反应，其特征是新血管渗透到无血管的角膜，最终到达肿瘤，使其进一步快速生长。研究了在小鼠角膜中实现血管生成的方法，以及新生血管反应的组织学和大体表现，以及肿瘤细胞或宿主辐照对观察到的血管生成反应的影响。肿瘤诱导新生血管形成的顺序分期被描述和记录为肉瘤180-和C755乳腺腺癌诱导的血管生成。本文讨论了肿瘤血管生成反应的许多不同过程，表明血管生成诱导因子的几个家族可能介导这些过程中的每一个。强调了研究血管生成的小鼠模型的重要性。
Tumor fragments implanted in the mouse cornea induce a neovascular reaction characterized by the penetration of new blood vessels into the avascular cornea that ultimately reach the tumor to permit its further rapid growth. A method to achieve angiogenesis in the mouse cornea was studied, as well as the histologic and gross manifestations of the neovascular reaction and the effect of tumor cells or host irradiation on the observed angiogenic response. Sequential stages of tumor-induced neovascularization are described and documented for sarcoma 180- and C755 mammary adenocarcinoma-induced angiogenesis. A number of distinct processes of the angiogenesis response to tumors are discussed which suggest that several families of angiogenesis-inducing factors may mediate each of these processes. The importance of the development of a mouse model for the study of angiogenesis is stressed.