The HIV-inactivating protein, cyanovirin-N, does not block gp120-mediated virus-to-cell binding
The HIV-inactivating protein, cyanovirin-N, does not block gp120-mediated virus-to-cell binding
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DOI：
10.1006/bbrc.1998.9060
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发表时间：
1998-07-30
影响因子：
3.1
通讯作者：
Boyd, MR
中科院分区：
文献类型：
--
作者：
Mariner, JM;McMahon, JB;Boyd, MR
Concentrations of the potent, HN(human immunodeficiency virus) inactivating protein, cyanovirin-N (CV-N), which completely inhibit HIV-1 infectivity, do not block the binding of soluble CD4-receptor (sCD4) to HIV-1 lysates nor the attachment of intact HIV-1 virions to several target T-cell lines. Furthermore, in contrast to the known disassociative effects of sCD4 on viral envelope glycoproteins, treatment of HIVRF with high concentrations of CV-N results in complete viral inactivation but without apparent shedding of gp120 or other ultrastructural changes. These results are consistent with the view that the virucidal effects of CV-N result from interference with step(s) in the fusion process subsequent to the initial binding of the virus to target cells. (C) 1998 Academic Press.
