CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA
CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA
复制标题
DOI：
10.1016/s0165-5728(03)00007-9
复制
发表时间：
2003-03-01
影响因子：
3.3
通讯作者：
Aloe, L
中科院分区：
文献类型：
--
作者：
Bracci-Laudiero, L;Celestino, D;Aloe, L
在这项研究中，我们调查了是否造血干细胞（HSC）和祖细胞存在于人脐带血中可以表达神经生长因子（NGF）特异性受体，TrkA和p75。结果显示，TrkA和NGF在脐血CD 34（+）细胞中有明显表达。TrkA和NGF在脐血CD34（+）细胞中表达最高，在脐血单个核细胞（MNC）中表达降低，在成人外周血单个核细胞中表达最低，提示NGF可能在造血祖细胞的分化中发挥作用，并提示免疫细胞对NGF的不同需求，这取决于它们的成熟状态。(C)2003 Elsevier Science B.V.保留所有权利。
In this study, we investigated whether hematopoietic stem cells (HSC) and progenitors present in human cord blood can express nerve growth factor (NGF)-specific receptors, TrkA and p75. Our results showed a marked expression of TrkA and NGF in cord blood CD34(+) cells. A gradient of TrkA and NGF expression exists and is highest in cord blood CD34(+) cells, reduced in cord blood mononuclear cells (MNC) and minimal in mononuclear cells isolated from adult peripheral blood.Our findings suggest that NGF may play a role in the differentiation of hematopoietic progenitors and indicate a different requirement for NGF by immune cells, depending on their state of maturity. (C) 2003 Elsevier Science B.V. All rights reserved.