Damped oscillations in serum thyroid hormone levels of normal newborn infants.
Damped oscillations in serum thyroid hormone levels of normal newborn infants.
复制标题
正常新生儿血清甲状腺激素水平的波动受到抑制。
DOI：
--
复制
发表时间：
1978
影响因子：
5.8
通讯作者：
D. Fisher
中科院分区：
文献类型：
--
作者：
T. H. Oddie;B. Bernard;M. Presley;A. Klein;D. Fisher
暴露于子宫外环境与下丘脑-垂体-甲状腺系统的显著刺激有关，之后必须重新建立垂体-甲状腺平衡。这种显著的内源性扰动提供了研究垂体-甲状腺轴重新平衡的方式的机会。本文用放射免疫分析法测定了440例健康新生儿从出生到236小时的血清T_4、T_3和TSH浓度。通过非线性曲线拟合程序分析结果，以评估平均激素浓度随年龄（t）的变化。Danziger和Elmergreen已经推导出方程，以评估激素平衡期间的振荡行为。将这些方程应用于本数据，我们观察到每个激素的方程中存在振荡余弦项。这表明在出生后的前5天，血清T4、T3和TSH浓度有显著的波动。振荡周期约为16 h。T4的振荡滞后于TSH的1/2至3/4周期; T3滞后于T4。因此，下丘脑-垂体-甲状腺平衡的紊乱似乎伴随着激素浓度的周期性振荡;当负反馈系统建立新的平衡条件时，这些振荡的幅度减小。
Exposure to the extrauterine environment is associated with marked stimulation of the hypothalamic-pituitary-thyroid system after which, pituitary-thyroid equilibrium must be reestablished. This marked endogenous perturbation offers the opportunity to study the manner in which the pituitary-thyroid axis is reequilibrated. T4, T3 and TSH concentrations have been measured by RIA in sera from 440 healthy newborn infants, whose ages ranged from birth to 236 h. Results were analyzed by nonlinear curve-fitting procedures to assess the changes in mean hormone concentrations with age (t). Equations have been derived by Danziger and Elmergreen to allow assessment of oscillatory behavior during hormone equilibration. Applying these equations to the present data, we observed the presence of an oscillatory cosine term in the equation for each hormone. This indicates significant oscillations in serum T4, T3, and TSH concentrations during the first 5 days of life. The period of the oscillations approximates 16 h. The oscillations in T4, lag 1/2 to 3/4 cycle behind TSH; T3 lags behind T4. Thus, disturbances in hypothalamic-pituitary-thyroid equilibrium seem to be followed by periodic oscillations in hormone concentrations; these oscillations decrease in amplitude as the negative feedback system establishes new equilibrium conditions.