Growth factors in wound healing
Growth factors in wound healing
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DOI：
10.1016/s0039-6109(02)00202-5
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发表时间：
2003-06-01
影响因子：
3.1
通讯作者：
Mustoe, TA
中科院分区：
文献类型：
--
作者：
Cross, KJ;Mustoe, TA
伤口愈合的增强仅限于良好的手术技术、使用适当敷料保持伤口清洁和清创。通过认识到在潮湿环境中的愈合比干燥伤口的愈合更好，已经提高了愈合伤口的能力。伤口愈合的药理学方法直到最近几十年才存在，当时人们认识到生长因子通常存在于伤口环境中，并且在动物模型和一些临床研究中，添加生长因子可以促进愈合。1998年，血小板衍生生长因子被批准用于临床。这种方法仍然是深入研究和临床试验的主题。本文分析了目前的知识，生长因子作为治疗剂，并推测其未来的潜力，成功和失败的分析日期。
Enhancement of wound healing was limited to good surgical technique, maintenance of a clean wound with appropriate dressings, and debridement. The ability to heal wounds has been advanced through the recognition that healing in a moist environment is improved over that of a desiccated wound. Pharmacologic approaches to wound healing did not exist until the last few decades, when it was recognized that growth factors are normally present in the wound environment and that in animal models and a few clinical studies, the addition of growth factors could enhance healing. In 1998, platelet-derived growth factor was approved for clinical use. This approach is still the subject of intense investigation and clinical trials. This article analyzes current knowledge on growth factors as therapeutic agents and speculates on their future potential, with an analysis of successes and failures to date.