Specific accumulation of organochlorines in human breast milk from Indonesia: levels, distribution, accumulation kinetics and infant health risk.
Specific accumulation of organochlorines in human breast milk from Indonesia: levels, distribution, accumulation kinetics and infant health risk.
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DOI：
10.1016/j.envpol.2005.04.028
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发表时间：
2006
影响因子：
8.9
通讯作者：
A. Sudaryanto;T. Kunisue;N. Kajiwara;H. Iwata;Tussy A Adibroto;P. Hartono;S. Tanabe
中科院分区：
文献类型：
--
作者：
A. Sudaryanto;T. Kunisue;N. Kajiwara;H. Iwata;Tussy A Adibroto;P. Hartono;S. Tanabe
本研究确定了印度尼西亚四个地点普通人群妇女的牛奶样本中多氯联苯（PCBs）和有机氯化合物（OC）农药的浓度。有机化合物中最常见的残留是ddt、多氯联苯和六氯环己烷异构体（HCHs），而其他有机化合物如氯丹化合物（CHLs）、三（4-氯苯）甲烷和六氯苯含量较低。OCs的水平因地点和个体而异，郊区和农村地区的DDTs高于城市地区，这可能是由于个人和地点之间饮食习惯和来源的差异。来自Purwakarta站点的数据表明持续接触滴滴涕，这可能证实印度尼西亚最近使用了滴滴涕。乳汁中OCs浓度与母亲年龄呈正相关，初产妇的OCs浓度高于多产妇，提示这些参数对哺乳期妇女的OCs负荷有重要影响。有些人在母乳中积累的ddt和HCHs接近甚至高于加拿大卫生部建议的TDI（每日可耐受摄入量）指南。
This study determined concentrations of polychlorinated biphenyls (PCBs) and organochlorine compound (OC) pesticides in the milk samples of women from the general population in four locations of Indonesia. The most prevalent residues of OCs were DDTs, PCBs and hexachlorocyclohexane isomers (HCHs), whereas other OCs such as chlordane compounds (CHLs), tris(4-chlorophenyl)methane and hexachlorobenzene were lower. The levels of OCs varied between locations and individuals, with DDTs higher in suburban and rural areas than urban localities, may be due to the differences in food habits and sources between the individuals and locations. Data from Purwakarta site indicated continuing DDT exposure, which may confirm recent usage of DDT in Indonesia. A positive correlation was observed between concentration of OCs in human milk and age of mothers, primiparas women having higher OCs than multiparas, suggesting these parameters play an important role influencing the OC burdens in lactating women. Some individuals accumulated DDTs and HCHs in breast milk close to or even higher than the TDI (tolerable daily intake) guidelines proposed by Health Canada.