DETECTION OF LINKAGE UNDER HETEROGENEITY - COMPARISON OF THE 2-LOCUS VS ADMIXTURE MODELS
DETECTION OF LINKAGE UNDER HETEROGENEITY - COMPARISON OF THE 2-LOCUS VS ADMIXTURE MODELS
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DOI：
10.1002/gepi.1370090107
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发表时间：
1992-01-01
影响因子：
2.1
通讯作者：
GOLDIN, LR
中科院分区：
文献类型：
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作者：
GOLDIN, LR
用遗传异质性模型模拟一种常见疾病的家系资料，比较了两位点模型和混合模型的连锁分析结果。确定家庭的设计，使样本有一个大比例的家庭分离的两个疾病位点。两个位点的连锁分析模型并没有表现出更高的功率检测连锁或更准确的估计重组分数，0比混合模型连锁分析。当样本是故意选择，使所有的家庭都分离的两个位点，然后两个位点的lod得分分析是更好的。然而，增加的功率取决于假设正确的基因频率的连锁位点。可以得出结论，在这里检查的遗传异质性的条件下，混合模型下的连锁测试是首选的分析方法。然而，这并不是一个普遍的结论，可以适用于所有的双位点疾病模型。
Linkage analysis under the two-locus model and the admixture model was compared on pedigree data for a common disease simulated under a model of genetic heterogeneity. The ascertainment of families was designed so that the samples had a large proportion of families segregating for both disease loci. The two-locus linkage analysis model did not demonstrate increased power of detecting linkage or more accurate estimates of the recombination fraction, 0 than did the admixture model linkage analysis. When a sample was purposely chosen so that all of the families were segregating for both loci, then the two-locus lod score analysis was better. However, the increased power depended on assuming the correct gene frequency for the linked locus. It can be concluded that under the conditions of genetic heterogeneity examined here, testing for linkage under the admixture model is the preferred method of analysis. However, this is not a general conclusion that can apply to all two-locus disease models.