MULTIORGAN GRANULOMAS AND MITOCHONDRIAL ANTIBODIES
MULTIORGAN GRANULOMAS AND MITOCHONDRIAL ANTIBODIES
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DOI：
10.1056/nejm198303103081006
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发表时间：
1983-01-01
影响因子：
158.5
通讯作者：
TURNERWARWICK, M
中科院分区：
文献类型：
--
作者：
FAGAN, EA;MOOREGILLON, JC;TURNERWARWICK, M
在常规经皮肝活检的标本中，可发现高达10%的肉芽肿。1线粒体的非器官特异性抗体发生在不到1%的一般人群中，在结节病患者中的比例相似。2这种抗体存在于95%以上的原发性胆汁性肝硬化患者中，2，3这种疾病可能与结节病在组织学和临床上相似。60%的结节病患者4和42%的原发性胆管炎患者5发生肝肉芽肿。线粒体抗体和阴性Kveim-Siltzbach试验的发现表明..... .
Granulomas may be found in up to 10 per cent of specimens from routine percutaneous liver biopsies.1Non-organ-specific antibodies to mitochondria occur in less than 1 per cent of the general population and in a similar proportion of patients with sarcoidosis.2Such antibodies are present in over 95 per cent of patients with primary biliary cirrhosis,2,3a disorder that may have histologic and clinical similarities to sarcoidosis. Hepatic granulomas occur in 60 per cent of patients with sarcoidosis4and in 42 per cent of those with primary biliary cirrhosis.5The finding of mitochondrial antibodies and a negative Kveim-Siltzbach test has . . .