Nicotine delivery and changes in withdrawal and craving during acute electronic cigarette, heated tobacco product, and cigarette use among a sample of Black and White people who smoke.
Nicotine delivery and changes in withdrawal and craving during acute electronic cigarette, heated tobacco product, and cigarette use among a sample of Black and White people who smoke.
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在吸烟的黑人和白人样本中，急性电子烟、加热烟草产品和卷烟使用过程中尼古丁的传递以及戒断和渴望的变化。
DOI：
10.1093/ntr/ntad247
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Nollen,NicoleL
中科院分区：
文献类型：
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作者：
Leavens,EleanorLS;Lambart,Leah;Diaz,FranciscoJ;Wagener,TheodoreL;Ahluwalia,JasjitS;Benowitz,Neal;Nollen,NicoleL
电子烟和加热烟草制品（HTPs）如果具有类似于香烟的奖励特征，则可以作为减少吸烟者危害的潜在选择。鲜为人知的是HTPs和电子烟与香烟在种族/少数民族smokers.Aims和MethodsTwenty-two尼古丁剥夺吸烟的人（黑色[n= 12]和白色[n= 10]）的滥用倾向完成了三次访问，其中包括一个标准化的10喷回合，然后由50分钟的自由使用评估与他们通常的品牌香烟（UBC），电子烟，和HTP。 访视以随机交叉设计完成，间隔至少48小时洗脱期。评估包括血浆尼古丁，Cmax，并减少渴望和withdraws.ResultsUBC提供了显着更高水平的尼古丁相比，电子烟（p<.001）和HTP（p<.01）在标准化和随意会话。 HTP在标准化抽吸期间（p= .047）比电子烟提供更多的尼古丁，但在随意抽吸期间则不然。 只有在标准化的吸烟会议，而不是随意会议期间的渴望显示出显着差异的产品（p<0.001），使UBC导致最大的减少其次是HTP和e-cigaretts.ConclusionsDespite更大的尼古丁交付从UBC相比，电子烟和HTP，参与者报告减少的渴望和撤回跨产品，特别是以下随意使用。 尽管尼古丁输送存在这种相对差异，但参与者报告了不同产品的渴望和戒断减少，特别是在随意使用之后。这些发现表明，在这个吸烟的黑人和白色人样本中，HTPs和电子烟显著缓解了维持吸烟的阴性症状。
IntroductionE-cigarettes and heated tobacco products (HTPs) may serve as potential options for harm reduction for smokers if they possess reward profiles similar to cigarettes. Little is known about the abuse liability of HTPs and e-cigarettes versus cigarettes in racial/ethnic minority smokers.Aims and MethodsTwenty-two nicotine-deprived people who smoke (black [n= 12] and white [n= 10]) completed three visits that included a standardized 10-puff bout followed by a 50-minute ad libitum use assessment with their usual brand cigarette (UBC), an e-cigarette, and HTP. Visits were completed in a randomized crossover design and were separated by a minimum 48-hour washout period. Assessments included plasma nicotine, Cmax, and reductions in craving and withdrawal.ResultsUBC delivered significantly greater levels of nicotine compared to the e-cigarette (p< .001) and HTP (p< .01) during both the standardized and ad libitum sessions. HTP delivered more nicotine than the e-cigarette during the standardized puffing session (p= .047) but not the ad libitum session. Only craving during the standardized puffing session and not the ad libitum session showed significant differences across products (p< .001) such that UBC resulted in the greatest reduction followed by HTP and e-cigarette.ConclusionsDespite greater nicotine delivery from the UBC compared to e-cigarette and HTP, participants reported reductions in craving and withdrawal across products, particularly following ad libitum use.ImplicationsUse of participant’s UBCs (UBC) resulted in greater nicotine delivery compared to both the e-cigarette and HTP. Despite this relative difference in nicotine delivery, participants reported reductions in craving and withdrawal across products, particularly following ad libitum use. These findings suggest that in this sample of black and white people who smoke, HTPs and e-cigarettes provided significant relief from negative symptoms that maintain smoking.