Nuclear retention of the transcription factor NLP7 orchestrates the early response to nitrate in plants
Nuclear retention of the transcription factor NLP7 orchestrates the early response to nitrate in plants
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DOI：
10.1038/ncomms2650
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发表时间：
2013-04-01
影响因子：
16.6
通讯作者：
Krapp, Anne
中科院分区：
文献类型：
--
作者：
Marchive, Chloe;Roudier, Francois;Krapp, Anne
硝酸盐是植物重要的营养物质和信号分子。虽然硝酸盐信号通路的几个组成部分已被确定，其层次结构仍不清楚。在这里，我们表明，本地化的NLP 7，RWP-RK转录因子家族的成员，通过核保留机制调节硝酸盐。全基因组分析显示，NLP 7结合并调节大多数已知的硝酸盐信号传导和同化基因。我们的研究结果表明，植物，如真菌和哺乳动物，依赖于类似的核保留机制，以立即响应关键营养素的可用性。
Nitrate is both an important nutrient and a signalling molecule for plants. Although several components of the nitrate signalling pathway have been identified, their hierarchical organization remains unclear. Here we show that the localization of NLP7, a member of the RWP-RK transcription factor family, is regulated by nitrate via a nuclear retention mechanism. Genome-wide analyses revealed that NLP7 binds and modulates a majority of known nitrate signalling and assimilation genes. Our findings indicate that plants, like fungi and mammals, rely on similar nuclear retention mechanisms to instantaneously respond to the availability of key nutrients.