Improvement of cardiovascular risk prediction: time to review current knowledge, debates, and fundamentals on how to assess test characteristics
Improvement of cardiovascular risk prediction: time to review current knowledge, debates, and fundamentals on how to assess test characteristics
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心血管风险预测的改进：是时候回顾一下有关如何评估测试特征的当前知识、争论和基础知识了
DOI：
10.1097/hjr.0b013e3283347059
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发表时间：
2010
影响因子：
8.3
通讯作者：
M. Pencina
中科院分区：
文献类型：
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作者：
Michel J. Romanens;Franz Ackermann;J. Spence;R. Darioli;N. Rodondi;R. Corti;G. Noll;M. Schwenkglenks;M. Pencina
心血管风险评估可能会随着动脉粥样硬化成像、实验室测试或功能测试衍生的新测试的加入而得到改善。本文综述了相对风险、优势比、接受者-操作曲线、基于似然比的测试后风险计算、净重分类改进和综合歧视。这有助于确定一种新的检测方法在常规风险检测之外是否具有额外的临床价值，以及如何在统计上验证这一点。两个有临床意义的例子说明了新的方法。这项工作将作为制定心血管风险预测新指南的审查和基础工作，考虑到新出现的测试，这些指南将由瑞士心脏病学会“瑞士动脉粥样硬化”工作组主持下的“血管风险预测工作组”成员提出。
Cardiovascular risk assessment might be improved with the addition of emerging, new tests derived from atherosclerosis imaging, laboratory tests or functional tests. This article reviews relative risk, odds ratios, receiver-operating curves, posttest risk calculations based on likelihood ratios, the net reclassification improvement and integrated discrimination. This serves to determine whether a new test has an added clinical value on top of conventional risk testing and how this can be verified statistically. Two clinically meaningful examples serve to illustrate novel approaches. This work serves as a review and basic work for the development of new guidelines on cardiovascular risk prediction, taking into account emerging tests, to be proposed by members of the ‘Taskforce on Vascular Risk Prediction’ under the auspices of the Working Group ‘Swiss Atherosclerosis’ of the Swiss Society of Cardiology in the future.
影响因子：
--
作者：
Folsom, Aaron R.;Chambless, Lloyd E.;Sharrett, A. Richey
通讯作者：
Sharrett, A. Richey