Primary Non‐Hodgkin's lymphoma of the mediastinum
Primary Non‐Hodgkin's lymphoma of the mediastinum
复制标题
原发性纵隔非霍奇金淋巴瘤
作者：
L. Levitt;A. Aisenberg;N. Harris;R. Linggood;S. Poppema
1975 年至 1979 年间，马萨诸塞州总医院收治的 215 名非霍奇金淋巴瘤患者中，有 12 名 (6%) 发生局限于纵隔和邻近结构的非霍奇金淋巴瘤。淋巴管造影、放射性核素扫描和全身计算机断层扫描用于排除就诊时患有胸外疾病的患者。 12 名患者中有 11 名出现广泛的连续结外病变（IIE 期），累及心包、胸骨、胸壁、肺实质，或有 4 名患者出现上腔静脉阻塞。弥漫性大细胞淋巴瘤（8例）和弥漫性低分化淋巴细胞淋巴瘤（4例）是常见的组织学亚型；没有遇到没有胸外扩散的淋巴母细胞淋巴瘤的病例。利用传统的表面标记技术，所研究的四种淋巴瘤中没有一种能够被表征为 B 细胞肿瘤或 T 细胞肿瘤。 12 名患者中有 10 名在单独联合化疗后（三名患者）或在化疗和纵隔放射治疗后（七名患者）获得完全缓解。这 10 例患者中有 2 例随后复发，但在平均 28 个月的观察期后尚未达到中位生存期。纵隔原发性非淋巴母细胞非霍奇金淋巴瘤比以前认识的更为常见，在胸部内表现出侵袭性的连续扩散，并且对联合化疗（有或没有辅助纵隔照射）反应良好。
Non‐Hodgkin's lymphoma localized to the mediastinum and adjacent structures occurred in 12 of 215 (6%) non‐Hodgkin's lymphoma patients seen at the Massachusetts General Hospital between 1975 and 1979. Lymphangiography, radionuclide scanning and whole body computerized tomography were used to exclude patients with extrathoracic disease at presentation. Eleven of the 12 patients presented with extensive contiguous extranodal disease (Stage IIE) with involvement of either the pericardium, sternum, chest wall, pulmonary parenchyma or, in four cases, with superior venacaval obstruction. Diffuse large cell lymphoma (eight cases) and diffuse poorly differentiated lymphocytic lymphoma (four cases) were the prevalent histlogic subtypes; no instances of lymphoblastic lymphoma without extrathoracic spread were encountered. None of four lymphomas studied could be characterized as either B‐ or T‐cell tumors utilizing conventional surface marker techniques. Ten of the 12 patients achieved complete remissions, either after treatment with combination chemotherapy alone (three patients) or after both chemotherapy and mediastinal irradiation (seven patients). Two of these ten have subsequently relapsed, but median survival has not been reached after a mean period of observation of 28 months. Primary nonlymphoblastic non‐Hodgkin's lymphoma of the mediastinum is more common than previously realized, displays aggressive contiguous spread within the chest and responds well to combination chemotherapy with or without adjuvant mediastinal irradiation.
影响因子：
11.2
作者：
P. Carbone;H. Kaplan;K. Musshoff;D. Smithers;M. Tubiana
通讯作者：
P. Carbone;H. Kaplan;K. Musshoff;D. Smithers;M. Tubiana