Computer simulation of aggregation in Dictyostelium discoideum.
Computer simulation of aggregation in Dictyostelium discoideum.
复制标题
盘基网柄菌聚集的计算机模拟。
作者：
S. A. MacKay
在计算机上模拟了细胞黏菌盘状盘基钢菌的聚集发育阶段。仿真是在二维中进行的，并产生类似于延时电影的动画图形输出。它是基于对细胞行为的观察，这些行为由每个细胞的一套规则所表达，包括细胞运动、释放和对化学信号的反应。遵循这些规则，模拟重现了许多观察到的聚集模式：细胞运动的传播波；分支溪流的形成；慢速中心的夹带；螺旋中心形成。该模拟已被证明是实验工作的重要辅助。
The aggregation phase of development of the cellular slime mould Dictyostelium discoideum is simulated on a computer. The simulation is performed in 2 dimensions, and produces animated graphical output similar to time-lapse films. It is based on observations of cell behaviour as expressed by a set of rules for each cell, involving cell movement and release of and response to chemical signals. Following these rules, the simulation has reproduced many observed aggregation patterns: propagating waves of cell movement; formation of branching streams; entrainment of slower centres; and spiral centre formation. The simulation has proved to be an important adjunct to experimental work.