Quantifying the duration of pre-diabetes
Quantifying the duration of pre-diabetes
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DOI：
10.1111/j.1753-6405.2010.00532.x
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发表时间：
2010-06-01
影响因子：
3.5
通讯作者：
Vos, Theo
中科院分区：
文献类型：
--
作者：
Bertram, Melanie Y.;Vos, Theo
目的：对糖尿病前期患者的干预措施是有效的，然而，在澳大利亚没有发现糖尿病前期患者。本研究的目的是计算糖尿病前期的持续时间，以提供支持性证据的筛选programmes.Methods：我们进行了系统的回顾和随机效应荟萃分析，以确定是否增加死亡的风险是存在于糖尿病前期的人。本荟萃分析的结果以及信息的患病率，缓解糖尿病前期和糖尿病从澳大利亚队列研究的过渡，在软件程序DisMod计算duration.Results：从2,578篇文章中确定，11项研究符合纳入标准。全因死亡率的合并相对风险为1.26（1.17-1.34），研究间无异质性迹象。30岁以上男性糖尿病前期的平均持续时间为8.5年，30岁以上女性为10.3年。结论：澳大利亚糖尿病前期的持续时间足够长，需要进行筛查计划。这一发现是强大的流行病学parameters.Implications的非常大的变化的敏感性测试：如果干预措施筛选后被证明是具有成本效益的，一个强大的理由实施的筛选程序存在。
Objective: Interventions for individuals with pre-diabetes are efficacious, however, identification of people with pre-diabetes does not occur in Australia. This study aims to calculate the duration of pre-diabetes, in order to provide supporting evidence for a screening program.Methods: We carried out a systematic review and random effects meta-analysis to identify if an increased risk of mortality is present in people with pre-diabetes. The result of this meta-analysis as well as information on prevalence, remission of pre-diabetes and transition to diabetes from an Australian cohort study, were used in the software program DisMod to calculate duration.Results: From 2,578 articles identified, 11 studies met the inclusion criteria. The pooled relative risk of all-cause mortality was 1.26 (1.17-1.34) with no sign of heterogeneity between the studies. The average duration of pre-diabetes was 8.5 years in males aged 30+ and 10.3 years in females aged 30+. Conclusions: The duration of pre-diabetes in Australia is long enough to warrant a screening program. The finding is robust to sensitivity testing of very large variations in the epidemiological parameters.Implications: If the interventions following screening are shown to be cost-effective, a strong rationale for the implementation of a screening program exists.