Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua.
Treatment of Iron-Loaded Veterinary Sarcoma by Artemisia annua.
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DOI：
10.1007/s13659-014-0013-7
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发表时间：
2014-04
影响因子：
4.7
通讯作者：
Efferth T
中科院分区：
文献类型：
--
作者：
Breuer E;Efferth T
青蒿素是黄花蒿的一种成分，是一种众所周知的抗疟疾药物。青蒿素类药物也在体外和体内抑制癌症生长。青蒿的草药提取物抑制癌细胞系的生长。在这里，我们报告的使用胶囊含有粉末的青蒿治疗宠物肉瘤。作为标准治疗的手术切除肿瘤的辅助治疗与A.annua。患纤维肉瘤的一只猫和一只狗分别存活了40个月和37个月，没有肿瘤复发。另外两只患有纤维肉瘤和血管内皮肉瘤的狗也表现出完全缓解，分别在39个月和26个月后仍然活着。黄花蒿耐受性良好，无明显副作用。这四个案例表明，黄花蒿可能是一个很有前途的草药治疗癌症。
Artemisinin, a constituent of Artemisia annua L., is a well-known antimalarial drug. Artemisinin-type drugs also inhibit cancer growth in vitro and in vivo. Herbal extracts of A.annua inhibit the growth of cancer cell lines. Here, we report on the use of capsules containing powder of Herba Artemisiae annuae to treat pet sarcoma. The surgical tumor removal as standard treatment was supplemented by adjuvant therapy with A.annua. One cat and one dog with fibrosarcoma survived 40 and 37 months, respectively, without tumor relapse. Two other dogs suffering from fibrosarcoma and hemangioendothelial sarcoma also showed complete remission and are still alive after 39 and 26 months, respectively. A.annua was well tolerated without noticeable side effects. These four cases indicate that A.annua may be a promising herbal drug for cancer therapy.