Copper-Promoted Coupling of Vinyl Boronates and Alcohols: A Mild Synthesis of Allyl Vinyl Ethers
Copper-Promoted Coupling of Vinyl Boronates and Alcohols: A Mild Synthesis of Allyl Vinyl Ethers
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DOI：
10.1021/ja907982w
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发表时间：
2010-02-03
影响因子：
15
通讯作者：
Merlic, Craig A.
中科院分区：
文献类型：
--
作者：
Shade, Ryan E.;Hyde, Alan M.;Merlic, Craig A.
报道了一种铜促进的乙烯基频哪醇硼酸酯与醇的偶联反应，合成烯醇醚。该反应以50-99%的产率发生，并且与各种官能团相容。乙酸铜是铜源，三乙胺缓冲液用于防止脱硼;反应在室温下进行。除了优异的化学选择性之外，该反应是立体特异性的。
A copper-promoted coupling of vinyl pinacol boronate esters and alcohols for the synthesis of enol ethers is reported. The reaction occurs In 50-99% yield and is compatible with a variety of functional groups. Cupric acetate is the copper Source, and triethylamine buffer is used to prevent protodeboration; the reaction occurs at room temperature. In addition to excellent chemoselectivity, the reaction is stereospecific.