EPITHELIAL IMMATURITY AND MULTIORGAN FAILURE IN MICE LACKING EPIDERMAL GROWTH-FACTOR RECEPTOR
EPITHELIAL IMMATURITY AND MULTIORGAN FAILURE IN MICE LACKING EPIDERMAL GROWTH-FACTOR RECEPTOR
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DOI：
10.1038/376337a0
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发表时间：
1995-07-27
期刊：
影响因子：
64.8
通讯作者：
DERYNCK, R
中科院分区：
文献类型：
--
作者：
MIETTINEN, PJ;BERGER, JE;DERYNCK, R
自从发现表皮生长因子（EGF）可以加速眼睑的打开（1）以来，EGF受体（EGF-R）已被广泛研究，现在被认为是原型酪氨酸激酶受体（2）。EGF或转化生长因子-α（TGF-α）或其他相关因子的结合激活受体并诱导细胞增殖和分化。虽然在造血细胞中没有发现EGF-R，但EGF-R在哺乳动物中广泛表达，并参与胚胎发育的各个阶段（3）。在这里，我们调查的发展和生理作用，这种受体及其配体失活的基因编码EGF-R。我们发现EGF-R（-/-）小鼠出生后存活长达8天，并在几个器官（包括皮肤、肺和胃肠道）中遭受上皮发育受损。
SINCE the discovery that epidermal growth factor (EGF) can accelerate opening of the eyelids(1), the EGF receptor (EGF-R) has been extensively studied and is now considered to be a prototype tyrosine kinase receptor(2). Binding of EGF or of transforming growth factor-alpha (TGF-alpha) or other related factors activates the receptor and induces cell proliferation and differentiation. Although it is not found on haematopoietic cells, the EGF-R is widely expressed in mammals and has been implicated in various stages of embryonic development(3). Here we investigate the developmental and physiological roles of this receptor and its ligands by inactivating the gene encoding EGF-R. We find that EGF-R(-/-) mice survive for up to 8 days after birth and suffer from impaired epithelial development in several organs, including skin, lung and gastrointestinal tract.