Microbeam radiation therapy: Clinical perspectives
Microbeam radiation therapy: Clinical perspectives
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DOI：
10.1016/j.ejmp.2015.02.011
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发表时间：
2015-09-01
影响因子：
3.4
通讯作者：
Laissue, J. A.
中科院分区：
文献类型：
--
作者：
Grotzer, M. A.;Schueltke, E.;Laissue, J. A.
微束放射治疗(MRT)是空间分割放射治疗(RT)的一种新形式，它使用同步加速器产生的X射线微束(MB)阵列。MRT已被确定为一种很有前途的治疗概念，可应用于恶性中枢神经系统(CNS)肿瘤患者，目前尚无令人满意的治疗方法。临床前实验研究表明，健康啮齿动物和仔猪的中枢神经系统可以耐受空间上分离的MBS发射的辐射剂量，而不是单一的、不间断的、宏观上宽的射束。高剂量、高精度的放射治疗，如MRT，减少了正常组织并发症的可能性，提供了改善治疗比率的前景，许多国际组织在过去20年发表的实验结果广泛地证明了这一点。发展捷运作为一种新的RT方式的重要性不容小觑。多达50%的癌症患者接受传统的放射治疗，任何在保留健康组织的同时提供更好的肿瘤控制的新疗法都可能显著改善患者的预后。(C)2015年，由爱思唯尔有限公司代表意大利医学协会出版。
Microbeam radiation therapy (MRT), a novel form of spatially fractionated radiotherapy (RT), uses arrays of synchrotron-generated X-ray microbeams (MB). MRT has been identified as a promising treatment concept that might be applied to patients with malignant central nervous system (CNS) tumours for whom, at the current stage of development, no satisfactory therapy is available yet. Preclinical experimental studies have shown that the CNS of healthy rodents and piglets can tolerate much higher radiation doses delivered by spatially separated MBs than those delivered by a single, uninterrupted, macroscopically wide beam. High-dose, high-precision radiotherapies such as MRT with reduced probabilities of normal tissue complications offer prospects of improved therapeutic ratios, as extensively demonstrated by results of experiments published by many international groups in the last two decades. The significance of developing MRT as a new RT approach cannot be understated. Up to 50% of cancer patients receive conventional RT, and any new treatment that provides better tumour control whilst preserving healthy tissue is likely to significantly improve patient outcomes. (C) 2015 Published by Elsevier Ltd on behalf of Associazione Italiana di Fisica Medica.