DNA Molecular Recognition of Intercalators Affects Aggregation of Thermoresponsive Polymer
DNA Molecular Recognition of Intercalators Affects Aggregation of Thermoresponsive Polymer
复制标题
嵌入剂的 DNA 分子识别影响热响应聚合物的聚集
DOI：
10.1039/c4py00600c
复制
发表时间：
2014
影响因子：
4.6
通讯作者：
and Takeo Yamaguchi
中科院分区：
文献类型：
--
作者：
Yuuki Sugawara;Takanori Tamaki;and Takeo Yamaguchi
插层剂与dsDNA的结合改变了DNA-PNIPAM的聚集现象，因为这种结合降低了dsDNA构象熵和/或dsDNA电荷的屏蔽。因此，dsDNA-PNIPAM被戏剧性地聚集在一起，以响应DNA嵌入物的分子识别。
Binding of intercalators to dsDNA switches the aggregation phenomena of DNA–PNIPAM because the binding decreases the dsDNA conformational entropy and/or the shielding of dsDNA charges. Thus, dsDNA–PNIPAM was dramatically aggregated in response to molecular recognition of the DNA–intercalator.