An analysis of the interrelationship between maternal age, body mass index and racial origin in the development of gestational diabetes mellitus
An analysis of the interrelationship between maternal age, body mass index and racial origin in the development of gestational diabetes mellitus
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DOI：
10.1111/j.1471-0528.2011.03156.x
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发表时间：
2012-02-01
影响因子：
5.8
通讯作者：
Steer, P. J.
中科院分区：
文献类型：
--
作者：
Makgoba, M.;Savvidou, M. D.;Steer, P. J.
目的探讨孕妇年龄、体重指数（BMI）和种族与妊娠期糖尿病（GDM）发病的个体相关性以及这些因素之间的相互作用。设计回顾性研究。1988年至2000年，伦敦西北部15个产科单位。所有妇女均未经产。在第一次产前检查时计算BMI，母亲年龄和种族来源（白色欧洲人，非洲黑人，加勒比黑人或南亚人）自我报告。方法二元logistic回归分析。主要结果测量每个种族组内GDM的发展。与年龄在20-24岁之间的欧洲白色人相比，年龄在30岁以上的白色欧洲人妇女发生GDM的优势比显著更高（P < 0.001），年龄在25岁以上的非洲黑人妇女发生GDM的优势比显著更高（P < 0.001），年龄在20岁以上的南亚人妇女发生GDM的优势比显著更高（P < 0.001）。与BMI正常的白色欧洲人相比，非洲黑人和南亚人（P < 0.001）的GDM发展的比值比显着较高（P < 0.001）。这两个因素在GDM的发展中都很重要，特别是在非洲黑人和南亚妇女中。
Objective To examine the individual association between advancing maternal age, body mass index (BMI) and racial origin with the development of gestational diabetes mellitus (GDM) and the interaction between these factors.Design Retrospective study.Setting Fifteen maternity units in northwest London between 1988 and 2000.Population The study included 1688 women who developed GDM and 172 632 who did not. All women were nulliparous. BMI was calculated at first antenatal visit and maternal age and racial origin (White European, Black African, Black Caribbean or South Asian) were self-reported.Methods Binary logistic regression analysis.Main outcome measures Development of GDM within each racial group.Results There was a strong positive association between advancing maternal age and increasing BMI, individually, and the development of GDM (P < 0.01 for both). Compared with White Europeans aged 20-24 years, the odds ratios for GDM development were significantly higher in women older than 30 years if they were White Europeans (P < 0.001), older than 25 years if they were Black Africans (P < 0.001) and older than 20 years if they were South Asians (P < 0.001). The odds ratios for GDM development were significantly higher in Black Africans and South Asians (P < 0.001 for both) irrespective of BMI, compared with White Europeans with normal BMI.Conclusion Maternal age and BMI interact with racial group in relation to the prevalence of GDM. Both factors are important in the development of GDM, particularly so in Black African and South Asian women.