Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy
Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy
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DOI：
10.1176/appi.ajp.159.4.630
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发表时间：
2002-04-01
影响因子：
17.7
通讯作者：
Toga, A
中科院分区：
文献类型：
--
作者：
Kumar, A;Thomas, A;Toga, A
目的：通过磁共振成像，在晚年心境障碍患者中发现了神经解剖学异常。本研究探讨了生物化学相关的晚年抑郁症的额叶灰质和白色matters. Methods：20例老年抑郁症患者和18名对照组在年龄和性别相似的患者进行了扫描的1.5-T磁共振扫描仪与头部线圈。体素被放置在左侧背外侧白色物质和双侧前扣带灰质。用I-C模型算法估计N-乙酰天冬氨酸、胆碱、肌醇和肌酸的绝对水平。代谢物肌酸水平的绝对值计算的比值。结果：肌醇/肌酸和胆碱/肌酸比值显着高于额叶白色物质的抑郁症组比对照组。结论：白色物质的生化改变可能为老年抑郁症的发生提供了神经生物学基础。
Objective: Neuroanatomical abnormalities have been identified in patients with late-life mood disorders by using magnetic resonance imaging. This study examined the biochemical correlates of late-life major depression in the frontal gray and white matter by using single-voxel proton spectroscopy.Method: Twenty elderly patients with major depression and 18 comparison subjects similar in age and gender to the patients were scanned on a 1.5-T magnetic resonance scanner with head coil. Voxels were placed in the left dorsolateral white matter and bilaterally in the anterior cingulate gray matter. Absolute levels of N-acetylaspartate, choline, myo-inositol, and creatine were estimated with the I-C-Model algorithm. Ratios of metabolite to creatine levels were computed from the absolute values.Results: myo-inositol/creatine and choline/creatine ratios were significantly higher in the frontal white matter in the major depression group than in the comparison group. The groups had no significant differences in the metabolite ratios in the gray matter,Conclusions: Biochemical changes in the white matter may provide some of the neurobiological substrates to late-life major depression.