Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats.
Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats.
复制标题
甘氨酸通过抑制大鼠心肌细胞凋亡减轻心肌缺血再灌注损伤
DOI：
10.7555/jbr.26.20110124
复制
发表时间：
2012-09
影响因子：
2.3
通讯作者：
Chen Q
中科院分区：
文献类型：
--
作者：
Zhong X;Li X;Qian L;Xu Y;Lu Y;Zhang J;Li N;Zhu X;Ben J;Yang Q;Chen Q
甘氨酸是一种有据可查的细胞保护剂。然而，它是否具有保护作用，对心肌缺血再灌注损伤在体内仍然是未知的。通过使用开胸麻醉大鼠模型，我们发现甘氨酸使缺血再灌注损伤大鼠的梗死面积比溶剂处理的MI/R大鼠减少21%。左室射血分数和左室短轴缩短率分别增加19.11%和30.98%。甘氨酸治疗可降低缺血再灌注损伤大鼠血浆肌酸激酶水平。重要的是，甘氨酸的管理显着抑制缺血再灌注后心肌细胞凋亡，这是伴随着抑制磷酸化p38丝裂原活化蛋白激酶和c-Jun氨基末端激酶，以及Fas配体。提示甘氨酸通过抑制心肌细胞凋亡减轻在体心肌缺血再灌注损伤。
Glycine is a well-documented cytoprotective agent. However, whether it has a protective effect against myocardial ischemia-reperfusion injury in vivo is still unknown. By using an open-chest anesthetized rat model, we found that glycine reduced the infarct size by 21% in ischemia-reperfusion injury rats compared with that in the vehicle-treated MI/R rats. The left ventricular ejection fraction and fractional shortening were increased by 19.11% and 30.98%, respectively, in glycine-treated rats. The plasma creatine kinase levels in ischemia-reperfusion injury rats decreased following glycine treatment. Importantly, administration of glycine significantly inhibited apoptosis in post-ischemia-reperfusion myocardium, which was accompanied by suppression of phosphorylated p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase, as well as the Fas ligand. These results suggest that glycine attenuates myocardial ischemia-reperfusion injury in vivo by inhibiting cardiomyocytes apoptosis.