Hypercalciuria in children with juvenile rheumatoid arthritis: association with hematuria.
Hypercalciuria in children with juvenile rheumatoid arthritis: association with hematuria.
复制标题
幼年类风湿性关节炎儿童的高钙尿症：与血尿的相关性。
DOI：
10.1016/s0022-3476(85)80132-3
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
L. Miller
中科院分区：
文献类型：
--
作者：
F. Stapleton;A. Hanissian;L. Miller
在发现2例儿童幼年类风湿性关节炎（JRA）、血尿和尿石症伴高钙尿症后，对38例JRA患者进行了尿钙测定。空腹尿钙/肌酐（mg/mg）（UCa/UCr）比值在12例患者中升高（>0.21），其平均UCa/UCr比值为0.34±0.14，而26例尿钙正常的JRA患者为0.09±0.06。系统性JRA患者UCa/UCr比值升高更常见（P<0.05），但未观察到UCa/UCr比值与功能分级或药物治疗相关。四名儿童增加尿钙肌酐比值进行了更广泛的检查。24小时尿钙排泄量范围为4.0 - 7.2 mg/kg/24小时。口服钙负荷试验显示这四名患者在饮食钙限制后出现空腹高钙尿症。血清钙、碳酸氢盐、磷和甲状旁腺激素值正常。12例高尿钙组血尿6例，而26例正常尿钙组血尿3例（P<0.016）。我们的结论是，尿钙排泄经常增加与JRA患者，高钙尿可能与血尿的发病机制，其中一些。
After discovering juvenile rheumatoid arthritis (JRA), hematuria, and urolithiasis associated with hypercalciuria in two children, urinary calcium excretion was examined in 38 patients with JRA. Fasting urine calcium/creatinine (mg/mg) (UCa/UCr) ratios were increased (>0.21) in 12 patients, who had a mean UCa/UCr ratio of 0.34±0.14, compared with 0.09±0.06 in 26 normocalciuric patients with JRA. Increased UCa/UCr ratios were found more frequently in patients with systemic JRA (P<0.05); however, no relationship between UCa/UCr ratios and either functional classification or drug therapy was observed. Four children with increased urine calcium to creatinine ratios were examined more extensively. Twenty-four-hour urine calcium excretion ranged from 4.0 to 7.2 mg/kg/24 hours. An orally administered calcium loading test demonstrated fasting hypercalciuria after dietary calcium restriction in these four patients. Serum calcium, bicarbonate, phosphorus, and parathyroid hormone values were normal. Hematuria was found in six of 12 hypercalciuric patients with JRA but in only three of 26 normocalciuric patients (P<0.016). We conclude that urinary calcium excretion is frequently increased in patients with JRA and that hypercalciuria may be related to the pathogenesis of hematuria in some of them.