Prognostic phenotypic and genotypic factors associated with photodynamic therapy response in patients with age-related macular degeneration.
Prognostic phenotypic and genotypic factors associated with photodynamic therapy response in patients with age-related macular degeneration.
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DOI：
10.2147/opth.s71305
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Yoneya S
中科院分区：
文献类型：
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作者：
Tsuchihashi T;Mori K;Horie-Inoue K;Okazaki Y;Awata T;Inoue S;Yoneya S
本研究旨在探讨光动力疗法（PDT）治疗老年性黄斑变性（AMD）的相关表型和基因型因素。该研究包括149例接受PDT治疗的渗出性AMD患者。三个单核苷酸多态性的八个表型因子和十个基因型因子（SNP; rs 800292、rs 1061170、rs 1410996），高温需要A-1（HTRA 1）基因中的rs 11200638-SNP，对血管内皮生长因子（VEGF）基因中的4个SNP（rs699947、rs 2010963）和色素上皮衍生因子（PEDF）基因中的4个SNP（rs 12948385、rs 12150053、rs 9913583、rs 1136287）进行了评价。最大线性尺寸、有无色素上皮脱落和HTRA 1-rs 11200638基因型与最佳矫正视力变化有统计学意义（P值分别为3.67×10−4、1.95×10−2、1.24×10−3）。HTRA 1-rs 11200638基因AA型患者的最佳矫正视力较GG型患者显著降低（P=1.33×10−3）。Logistic回归分析显示，HTRA 1-rs 11200638基因型与光动力治疗后12个月的最佳矫正视力结果（P=4.60×10−3;比值比2.363; 95%置信区间1.303-4.285）相关性最强。HTRA 1-rs 11200638变异显示出最显著的关联。因此，该变体可用作预后因子以估计具有显著预测能力的PDT反应。
This study aimed to demonstrate the phenotypic and genotypic factors associated with photodynamic therapy (PDT) for age-related macular degeneration (AMD). The study included 149 patients with exudative AMD treated by PDT. Eight phenotypic factors and ten genotypic factors for three single nucleotide polymorphisms (SNPs; rs800292, rs1061170, rs1410996) in the complement factor H (CFH) gene, rs 11200638-SNP in the high temperature requirement A-1 (HTRA1) gene, two SNPs (rs699947, rs2010963) in the vascular endothelial growth factor (VEGF) gene, and four SNPs (rs12948385, rs12150053, rs9913583, rs1136287) in the pigment epithelium-derived factor (PEDF) gene were evaluated. A significant association with best-corrected visual acuity change was demonstrated in the greatest linear dimension, presence or absence of pigment epithelial detachment, and HTRA1-rs11200638 genotype statistically (P=3.67×10−4, 1.95×10−2, 1.24×10−3, respectively). Best-corrected visual acuity in patients with AA genotype of HTRA1-rs11200638 significantly decreased compared with that in patients with GG genotype (P=1.33×10−3). Logistic regression analyses demonstrated HTRA1-rs11200638 genotype was most strongly associated with best-corrected visual acuity outcome from baseline at 12 months after photodynamic therapy (P=4.60×10−3; odds ratio 2.363; 95% confidence interval 1.303–4.285). The HTRA1-rs11200638 variant showed the most significant association. Therefore, this variant may be used as a prognostic factor to estimate the PDT response with significant predictive power.