Effect of biofilm formation on implant abutments with an anti-bacterial coating: A pre-clinical in vivo study
Effect of biofilm formation on implant abutments with an anti-bacterial coating: A pre-clinical in vivo study
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DOI：
10.1111/clr.13745
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发表时间：
2021-03-24
影响因子：
4.3
通讯作者：
Berglundh, Tord
中科院分区：
文献类型：
--
作者：
Almohandes, Ahmed;Abrahamsson, Ingemar;Berglundh, Tord
Objectives To analyze the long-term effect of plaque formation on implant abutments with a antimicrobial coating and the secondary host response in peripheral-implant tissues.Materials and Methods四个种植体被安装在每个下颌前磨牙区域拔牙后在6只狗。三个月后，将两个带有钛-铋-镓（Ti-Bi-Ga）涂层的试验基台和两个对照钛基台连接到下颌骨两侧的种植体上。2个月后，在下颌骨一侧的种植体周围放置结扎线，并允许斑块形成，直到实验结束。4周后取出结扎线。在菌斑形成期间，从每个植入部位获取X线片和微生物样本。基台连接后8个月进行活检，并准备进行组织学analysis.Results的分析没有发现任何统计学显着差异，骨丢失，细菌生长和炎症病变的大小之间的种植体单位和没有钛-铋-镓涂层。暴露于短期结扎引起的故障的种植体部位表现出更明显的骨丢失和细菌生长比non-ligature sites.Conclusions这表明，一个钛铋镓涂层不防止生物膜形成的种植装置，并不影响随后的主机响应在相邻的种植体周围粘膜。
Objectives To analyse the long-term effect of plaque formation on implant abutments with an antibacterial coating and the ensuing host response in peri-implant tissues.Materials and methods Four implants were installed in each mandibular premolar region following tooth extraction in six dogs. Three months later, two test abutments with a titanium-bismuth-gallium (Ti-Bi-Ga) coating and two control titanium abutments were connected to the implants on each side of the mandible. After 2 months, ligatures were placed around the implants in one side of the mandible and plaque formation was allowed until the end of the experiment. The ligatures were removed after 4 weeks. Radiographs and microbiological samples were obtained from each implant site during the plaque formation period. Biopsies were obtained 8 months after abutment connection and prepared for histological analysis.Results The analysis did not reveal any statistically significant differences in bone loss, bacterial growth and size of inflammatory lesions between implant units with and without the Ti-Bi-Ga coating. Implant sites exposed to the short period of ligature-induced breakdown demonstrated more pronounced bone loss and bacterial growth than non-ligature sites.Conclusions It is suggested that a Ti-Bi-Ga coating does not prevent biofilm formation on the implant device and does not influence the ensuing host response in the adjacent peri-implant mucosa.