X-ray vector radiography for bone micro-architecture diagnostics
X-ray vector radiography for bone micro-architecture diagnostics
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DOI：
10.1088/0031-9155/57/11/3451
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发表时间：
2012-06-07
影响因子：
3.5
通讯作者：
Pfeiffer, Franz
中科院分区：
文献类型：
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作者：
Potdevin, Guillaume;Malecki, Andreas;Pfeiffer, Franz
在系统层面对大型生物物理系统的理解通常取决于对其微观结构的精确了解。这是很难实现的，尤其是在体内，因为大多数成像方法要么在可实现的视野方面受到限制，要么利用穿透性电离辐射（例如 X 射线），在这种情况下，分辨率受到沉积剂量的严重限制。在这里，我们描述了一种新方法，即 X 射线矢量射线照相术 (XVR)，它可以产生有关样品微结构的局部取向、各向异性和平均尺寸的各种类型的信息。我们通过展示人类椎骨样本的第一个实验性 XVR 来证明其可行性，即使像素分辨率为半毫米（比结构本身大得多），也能提供有关小梁结构的信息。最后一点对于低剂量测量方法的开发至关重要，该方法将允许进行体内研究，并可能在未来用于骨质疏松症等骨代谢紊乱疾病的新医学诊断方法。
The understanding of large biophysical systems at the systems level often depends on a precise knowledge of their microstructure. This is difficult to obtain, especially in vivo, because most imaging methods are either limited in terms of achievable field of view, or make use of penetrating ionizing radiations such as x-rays, in which case the resolution is severely limited by the deposited dose. Here, we describe a new method, x-ray vector radiography (XVR), which yields various types of information about the local orientation, anisotropy and average size of the sample microstructures. We demonstrate the feasibility by showing first experimental XVRs of human vertebra bone samples, giving information on the trabecular structures even with a pixel resolution of half a millimetre, much larger than the structures themselves. This last point is critical for the development of low-dose measurement methods which will allow for in vivo studies and potentially in the future for new medical diagnostics methods of bone metabolic disorder diseases such as osteoporosis.