Lung injury in acute pancreatitis: mechanisms, prevention, and therapy
Lung injury in acute pancreatitis: mechanisms, prevention, and therapy
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DOI：
10.1097/00132980-200201040-00012
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发表时间：
2002-04
影响因子：
3.3
通讯作者：
C. Shields;D. Winter;P. Redmond
中科院分区：
文献类型：
--
作者：
C. Shields;D. Winter;P. Redmond
肺损伤是胰腺炎时腹腔外器官功能障碍最相关的表现。这种腹膜后炎性疾病导致弥漫性和危及生命的肺损伤的倾向是显著的。大约三分之一的患者将发展为急性肺损伤和急性呼吸窘迫综合征，这占第一周内所有死亡人数的60%。胰腺炎临床过程的变异性使其成为一个令人烦恼的实体，并使任何特定干预措施的疗效难以证明。胰腺炎相关性肺损伤的独特病理实体审查的重点是病因和潜在的治疗策略。
Lung injury is the most pertinent manifestation of extra-abdominal organ dysfunction in pancreatitis. The propensity of this retroperitoneal inflammatory condition to engender a diffuse and life-threatening lung injury is significant. Approximately one third of patients will develop acute lung injury and acute respiratory distress syndrome, which account for 60% of all deaths within the first week. The variability in the clinical course of pancreatitis renders it a vexing entity and makes demonstration of the efficacy of any specific intervention difficult. The distinct pathologic entity of pancreatitis-associated lung injury is reviewed with a focus on etiology and potential therapeutic maneuvers.