A worldwide survey of genome sequence variation provides insight into the evolutionary history of the honeybee Apis mellifera
A worldwide survey of genome sequence variation provides insight into the evolutionary history of the honeybee Apis mellifera
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DOI：
10.1038/ng.3077
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发表时间：
2014-10-01
期刊：
影响因子：
30.8
通讯作者：
Webster, Matthew T.
中科院分区：
文献类型：
--
作者：
Wallberg, Andreas;Han, Fan;Webster, Matthew T.
西方蜜蜂（Apis mellifera）具有重要的生态和经济意义。我们分析了830万个SNP的遗传变异模式，这些SNP是通过对来自全球14个种群样本的140个蜜蜂基因组进行测序确定的，总深度为634x。这些数据提供了深入了解该物种的进化历史和遗传基础的地方适应。我们发现的证据表明，人口规模波动很大，反映了气候的历史波动，虽然当代人口具有较高的遗传多样性，表明驯化瓶颈的情况下。遗传变异的水平受到自然选择的强烈影响，并与基因表达和DNA甲基化模式高度相关。我们确定的基因组签名的本地适应，这是丰富的基因表达的工人和免疫系统和精子活力相关的基因，可能是地理变异的生殖，传播和抗病性。这项研究为今后调查蜜蜂对病原体和气候变化的反应提供了一个框架。
The honeybee Apis mellifera has major ecological and economic importance. We analyze patterns of genetic variation at 8.3 million SNPs, identified by sequencing 140 honeybee genomes from a worldwide sample of 14 populations at a combined total depth of 634x. These data provide insight into the evolutionary history and genetic basis of local adaptation in this species. We find evidence that population sizes have fluctuated greatly, mirroring historical fluctuations in climate, although contemporary populations have high genetic diversity, indicating the absence of domestication bottlenecks. Levels of genetic variation are strongly shaped by natural selection and are highly correlated with patterns of gene expression and DNA methylation. We identify genomic signatures of local adaptation, which are enriched in genes expressed in workers and in immune system and sperm motility related genes that might underlie geographic variation in reproduction, dispersal and disease resistance. This study provides a framework for future investigations into responses to pathogens and climate change in honeybees.