CHARACTERIZATION OF THE INSULIN RESISTANCE OF AGING
CHARACTERIZATION OF THE INSULIN RESISTANCE OF AGING
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DOI：
10.1172/jci110914
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发表时间：
1983-01-01
影响因子：
15.9
通讯作者：
FLIER, JS
中科院分区：
文献类型：
--
作者：
ROWE, JW;MINAKER, KL;FLIER, JS
为了阐明胰岛素诱导的葡萄糖处置剂量反应的胰岛素抵抗的性质，以及胰岛素与循环单核细胞的结合，在健康的老年男性中研究了。在17名年轻和10名旧健康的非肥胖受试者中，总共进行了49个两项H得格糖胰岛素夹。虽然旧组的体重估计值较低，并且对总体脂肪的估计比年轻组更高，但这些差异不超过5％，并且没有达到统计学意义。以每分钟20 mu/m2的含量注入胰岛素（Young = 8，老= 5）；每分钟80 mu/m2（Young = 13，od = 9）;每分钟200 mu/m2（年轻= 9，老= 5）。高胰岛素血症的水平升高与年龄较大的稳态葡萄糖输注率的剂量依赖性增加有关。对于年轻人和老年人来说，最大葡萄糖输注率（mg/wt）相同。但是，剂量反应曲线在旧受试者的右边移动。在每个年龄段的4个个人中，在每个剂量水平进行研究的人中，公里为54。+ - 。 14 .mu.u/ml在年轻人中，113。+ - 。 11 .mu.u/ml旧（p <0.02）。对瘦体重的葡萄糖输注率的校正对年龄组之间的比较没有影响。这些数据表明，外周组织对胰岛素的敏感性下降，而不会改变最大组织反应能力。胰岛素与14名老年受试者的胰岛素结合的研究表明，年龄对胰岛素结合对受体的影响没有影响循环单核细胞（年轻=5.25。+ - 。0.35; old = 6.22。 107个细胞）。衰老可能与胰岛素作用中的后受体缺陷有关，这表现为全身组织对胰岛素的敏感性降低而不会改变组织反应能力。
To clarify the nature of the insulin resistance of aging the dose response for insulin-induced glucose disposal and the binding of insulin to circulating monocytes was studied in healthy young and old men. A total of 49 two h euglycemic insulin clamp studies were performed in 17 young and 10 old healthy nonobese subjects. While the old group had lower estimates of lean body mass and greater estimates of total body fat than the young group, these differences did not exceed 5% and did not reach statistical significance. Insulin was infused at 20 mU/m2 per min (young = 8, old = 5); 80 mU/m2 per min (young= 13, old = 9); 200 mU/m2 per min (young = 9, old = 5). Increasing levels of hyperinsulinemia were associated with dose-dependent increases in steady-state glucose infusion rates in young and old. The maximal glucose infusion rates (mg/body wt per min) were the same for young and old. However, the dose-response curve was shifted to the right in the old subjects. In the 4 individuals in each age group in whom studies were performed at each dose level, the Km was 54 .+-. 14 .mu.U/ml in the young and 113 .+-. 11 .mu.U/ml in the old(P < 0.02). Correction of glucose infusion rate for lean body mass had no effect on comparisons between age groups. These data indicate an age-associated decline in sensitivity of peripheral tissues to insulin without a change in maximal tissue responsiveness. Studies of insulin binding with 14 young and 9 old subjects indicated no effect of age on the insulin binding to receptors on circulating monocytes (young = 5.25 .+-. 0.35; old = 6.22 .+-. 0.53% of 125I-insulin bound/107 cells). Aging may be associated with a postreceptor defect in insulin action manifested by decreased whole-body tissue sensitivity to insulin without a change in tissue responsiveness.