The case for survivin as a regulator of microtubule dynamics and cell-death decisions
The case for survivin as a regulator of microtubule dynamics and cell-death decisions
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DOI：
10.1016/j.ceb.2006.08.015
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发表时间：
2006-12-01
影响因子：
7.5
通讯作者：
Altieri, Dario C.
中科院分区：
文献类型：
--
作者：
Altieri, Dario C.
Survivin在基础研究和转化研究的不同领域引起了人们的浓厚兴趣。这源于“存活素网络”的复杂性，其似乎与细胞分裂、抗凋亡、监视检查点和适应不利环境的多个途径交叉。这种复杂性也产生了不同的模型生存素功能及其影响。随着生存素拮抗剂在临床上的评估，对该途径的关键性重新评估，特别是关于细胞分裂和细胞存活，现在是一个优先事项。建立一个统一的模型来协调对生存素的不同观点，将有助于设计和解释针对人类这个网络的基于分子的临床试验。
Survivin has aroused keen interest in disparate areas of basic and translational research. This stems from the complexity of a I survivin network', which appears to intersect multiple pathways of cell division, resistance to apoptosis, surveillance checkpoints and adaptation to unfavorable environments. Such intricacy has also engendered different models for survivin function and its implications. As antagonists of survivin are being evaluated in the clinic, a critical reassessment of the pathway, especially with respect to cell division and cell survival, is now a priority. Building a unifying model to reconcile the differing views on survivin will aid in the design and interpretation of molecularly based clinical trials targeting this network in humans.