Increased prepulse inhibition of the acoustic startle response is associated with better strategy formation and execution times in healthy males
Increased prepulse inhibition of the acoustic startle response is associated with better strategy formation and execution times in healthy males
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DOI：
10.1016/j.neuropsychologia.2006.04.001
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发表时间：
2006-01-01
期刊：
影响因子：
2.6
通讯作者：
Frangou, Sophia
中科院分区：
文献类型：
--
作者：
Bitsios, Panos;Giakoumaki, Stella G.;Frangou, Sophia
前脉冲抑制（PPI）是指在较弱的感觉刺激（前脉冲）之前，对突然的强烈刺激（脉冲）的惊吓反射幅度的衰减。PPI反映了在处理的早期阶段过滤掉不相关信息的能力，以便将注意力引导到更显著的环境特征上。在信息处理的早期阶段，前额叶皮层以“自上而下”的方式调节抑制，这可能解释了PPI和认知表现的正常个体间差异。（剑桥长筒袜; SoC）、空间工作记忆（SWM）和来自剑桥神经心理学测试自动组合的5选择反应时间（RT）测试。PPI评分和认知测试变量之间的相关性进行了检查。此外，PPI分数被分为四分位数，这被用作检查认知测试表现的分组因素。与最低四分位数的个体相比，最高四分位数的个体具有（a）更短的执行时间，但不是5-选择RT的反应时间，（B）更短的后续时间，但不是SoC的初始思考时间，他们也用最少的移动次数正确解决了更多的问题，我们的研究结果表明，更大的PPI与策略形成和执行时间的上级能力相关。我们认为，这是由于更有效的早期信息处理。(c)2006爱思唯尔有限公司保留所有权利。
Prepulse inhibition (PPI) refers to the attenuation of the amplitude of the startle reflex in response to sudden intense stimuli (pulse) if preceded by a weaker sensory stimulus (prepulse). PPI reflects the ability to filter out irrelevant information in the early stages of processing so that attention can be directed to more salient environmental features. Inhibition at this early stage of information processing appears modulated by the prefrontal cortex in a "top-down" fashion and this may account for the normal inter-individual variability in PPI and in cognitive performance.PPI data were calculated from 82 healthy male subjects who were also tested in problem solving (Stockings of Cambridge; SoC), spatial working memory (SWM) and 5-choice reaction time (RT) tests from the Cambridge Neuropsychological Test Automated Battery. Correlations between PPI scores and cognitive test variables were examined. In addition PPI scores were divided in quartiles which were used as grouping factors in examining cognitive test performance.Compared to individuals in the lowest quartile those in the highest had (a) shorter execution but not reaction times on the 5-choice RT, (b) shorter subsequent but not initial thinking times in the SoC where they also solved more problems correctly with the minimum number of moves, and (c) better strategy but not errors scores in the SWM.Our findings suggest that greater PPI is associated with superior abilities in strategy formation and execution times. We suggest that this is due to more efficient early information processing. (c) 2006 Elsevier Ltd. All rights reserved.