The optimal extent of lymph node dissection for adenocarcinoma of the esophagogastric junction differs between Siewert type II and Siewert type III patients.
The optimal extent of lymph node dissection for adenocarcinoma of the esophagogastric junction differs between Siewert type II and Siewert type III patients.
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DOI：
10.1007/s10120-014-0364-0
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发表时间：
2014-03-22
期刊：
影响因子：
7.4
通讯作者：
Terashima, Masanori
中科院分区：
文献类型：
--
作者：
Goto, Hironobu;Tokunaga, Masanori;Miki, Yuichiro;Makuuchi, Rie;Sugisawa, Norihiko;Tanizawa, Yutaka;Bando, Etsuro;Kawamura, Taiichi;Niihara, Masahiro;Tsubosa, Yasuhiro;Terashima, Masanori
食管胃交界腺癌（AEG）的发病率在世界范围内呈上升趋势。我们研究了Siewert II型和III型aeg患者的临床病理特征，并明确了这些患者的最佳腹内淋巴结清扫方法。本研究纳入了2002年9月至2012年12月在静冈癌症中心接受根治性切除的132例AEG患者。采用淋巴结清扫预估获益指数（IEBLD）评价各部位淋巴结清扫的疗效。比较siwert II型和III型aeg患者的临床病理特征和各站的iebld。我们分析了92例Siewert II型AEG和40例Siewert III型AEG。两组患者的淋巴结转移发生率均较高（II型AEG为64.1%，III型AEG为75.0%）。siwert II型和III型aeg患者的5年生存率相似，分别为54.4%和53.4%。两组食管胃交界处附近淋巴结的iebld普遍较高，而siwert III型AEG患者胃下周淋巴结的iebld高于siwert II型AEG患者。除了下胃周淋巴结外，siwert II型和III型aeg在所有站点的IEBLDs相似。对于siwert III型AEG，应选择全胃切除术作为标准治疗方法，而对于siwert II型AEG，保留胃远端部分可能是一种可接受的治疗方法。
The incidence of adenocarcinoma of the esophagogastric junction (AEG) has been increasing worldwide. We investigated the clinicopathological characteristics of patients with Siewert type II and III AEGs and clarified the optimal intra-abdominal lymph node dissection in these patients. This study included 132 patients with AEG who underwent curative resection at Shizuoka Cancer Center from September 2002 to December 2012. We used the index of estimated benefit from lymph node dissection (IEBLD) to assess the efficacy of lymph node dissection of each station. The clinicopathological characteristics and IEBLDs of each station were compared between patients with Siewert type II and III AEGs. We analyzed 92 patients with Siewert type II AEG and 40 patients with Siewert type III AEG. The incidence of lymph node metastasis was high in both groups (64.1 % in type II AEG and 75.0 % in type III AEG). The 5-year survival rates were similar for the patients with Siewert type II and III AEGs, at 54.0 and 53.4 %, respectively. The IEBLDs of stations located near the esophagogastric junction were generally high in both groups, while the IEBLDs of lower perigastric lymph nodes were higher in Siewert type III than in Siewert type II AEG cases. The IEBLDs were similar between Siewert type II and III AEGs at all stations except for lower perigastric lymph nodes. Total gastrectomy should be selected as a standard treatment for Siewert type III AEG, whereas in Siewert type II AEG, preservation of the distal part of the stomach may be an acceptable procedure.
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影响因子：
7.4
作者：
Fujitani, Kazumasa;Miyashiro, Isao;Doki, Yuichiro
通讯作者：
Doki, Yuichiro
影响因子：
3.7
作者：
Hosokawa, Yuichi;Kinoshita, Takahiro;Kinoshita, Taira
通讯作者：
Kinoshita, Taira
DOI：
10.1007/pl00011720
发表时间：
2000-12-01
期刊：
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
影响因子：
--
作者：
Gotoda, Takuji;Yanagisawa, Akio;Kato, Yo
通讯作者：
Kato, Yo
影响因子：
9.6
作者：
Mine, S.;Sano, T.;Yamaguchi, T.
通讯作者：
Yamaguchi, T.
影响因子：
51.1
作者：
Sasako, Mitsuru;Sano, Takeshi;Hiratsuka, Masahiro
通讯作者：
Hiratsuka, Masahiro