Biological age - what is it and can it be measured?
Biological age - what is it and can it be measured?
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DOI：
10.1016/s0167-4943(02)00060-2
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发表时间：
2003-03-01
影响因子：
4
通讯作者：
Weale, RA
中科院分区：
文献类型：
--
作者：
Jackson, SHD;Weale, MR;Weale, RA
Biological age is a concept used loosely and with little objectivity to describe a shortfall between a population cohort average life expectancy and the perceived life expectancy of an individual of the same age. Many biomarkers decline roughly linearly with age with a slope of < 1% per annum. The use of a battery of 16 biomarkers is described as a method of calculating an individual biological age. They include: the concentration of prostacyclin in fibroblasts, cell membrane viscosity, the electroretinogram, baroreflex regulation of the heart rate, the concentration of lymphocytes, leucocyte density and velocity, grip strength, cells of the corneal endothelium and the buccal epithelium, neck muscle mobility, and vital capacity. Although not subjected to a prospective validation, the method might provide an objective approach to this widely used concept. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
