Comparison of the clearance of radiolabelled nose drops and nasal spray as mucosally delivered vaccine
Comparison of the clearance of radiolabelled nose drops and nasal spray as mucosally delivered vaccine
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DOI：
10.1097/00006231-199902000-00010
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发表时间：
1999-02-01
影响因子：
1.5
通讯作者：
McDougall, IR
中科院分区：
文献类型：
--
作者：
Bryant, ML;Brown, P;McDougall, IR
在三名志愿者中测定了Tc-99（m）标记的白蛋白（18.5 MBq）的分布和鼻清除率，该白蛋白用作FluMist（TM）的粘膜疫苗替代物。受试者在交叉临床研究设计中随机接受大颗粒气雾剂（鼻喷雾剂），然后是滴鼻剂，或滴鼻剂，然后是鼻喷雾剂，间隔1周。使用伽马射线照相术测量分布和清除率。以滴剂形式递送的“疫苗”以非常可变的速率从鼻子进入食道和胃上部。相比之下，鼻喷雾剂均匀分布并从鼻咽清除，50%平均清除时间为50 min（范围40-60 min），在肺中未检测到。((C)1999 Lippincott威廉姆斯和威尔金斯）。
The distribution and nasal clearance of Tc-99(m)-labelled albumin (18.5 MBq), used as a mucosal vaccine surrogate for FluMist(TM), was determined in three volunteers. The subjects were randomized in a crossover clinical study design to receive either large-particle aerosal (nasal spray) followed by nose drops, or nose drops followed by the nasal spray, 1 week apart. Gamma scintigraphy was used to measure the distribution and clearance. The 'vaccine' delivered as drops was cleared from the nose into the oesophagus and upper stomach at very variable rates. In contrast, the nasal spray was uniformly distributed and cleared from the nasopharynx with a 50% mean clearance time of 50 min (range 40-60 min) and was not detected in the lungs. ((C) 1999 Lippincott Williams & Wilkins).