An autonomous wearable system for diurnal sweat biomarker data acquisition
An autonomous wearable system for diurnal sweat biomarker data acquisition
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DOI：
10.1039/d0lc00820f
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发表时间：
2020-12-21
期刊：
影响因子：
6.1
通讯作者：
Emaminejad, Sam
中科院分区：
文献类型：
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作者：
Hojaiji, Hannaneh;Zhao, Yichao;Emaminejad, Sam
为了跟踪汗液中动态变化和生理相关的生物标志物分布，需要自主可穿戴平台在最少或没有用户干预的情况下定期采样和分析汗液。先前报道的汗液传感器在功能上限于在一个时间点/时段捕获生物标志物信息，从而需要重复的用户干预以增加生物标志物数据的时间粒度。因此，我们提出了一种紧凑的多隔室可穿戴系统，其中每个隔室可以被激活以自主地诱导/调节汗液分泌（通过离子电渗致动）并在设定的时间点分析汗液。该系统的开发遵循混合柔性设计和垂直集成方案集成所需的功能模块：小型化离子电渗接口，粘合剂薄膜微流体传感模块，和控制/读出电子。该系统被部署在人类受试者研究中，以跟踪与每日食物摄入量有关的汗液葡萄糖水平的昼夜变化。所展示的昼夜汗液生物标志物数据采集的自主操作说明了该系统适用于大规模和纵向个人健康监测应用。
To track dynamically varying and physiologically relevant biomarker profiles in sweat, autonomous wearable platforms are required to periodically sample and analyze sweat with minimal or no user intervention. Previously reported sweat sensors are functionally limited to capturing biomarker information at one time-point/period, thereby necessitating repeated user intervention to increase the temporal granularity of biomarker data. Accordingly, we present a compact multi-compartment wearable system, where each compartment can be activated to autonomously induce/modulate sweat secretion (via iontophoretic actuation) and analyze sweat at set time points. This system was developed following a hybrid-flex design and a vertical integration scheme-integrating the required functional modules: miniaturized iontophoresis interfaces, adhesive thin film microfluidic-sensing module, and control/readout electronics. The system was deployed in a human subject study to track the diurnal variation of sweat glucose levels in relation to the daily food intake. The demonstrated autonomous operation for diurnal sweat biomarker data acquisition illustrates the system's suitability for large-scale and longitudinal personal health monitoring applications.