An experimental study of adolescent sleep restriction during a simulated school week: changes in phase, sleep staging, performance and sleepiness
An experimental study of adolescent sleep restriction during a simulated school week: changes in phase, sleep staging, performance and sleepiness
复制标题
DOI：
10.1111/jsr.12473
复制
发表时间：
2017-04-01
影响因子：
4.4
通讯作者：
Short, Michelle A.
中科院分区：
文献类型：
--
作者：
Agostini, Alex;Carskadon, Mary A.;Short, Michelle A.
这项实验室研究调查了模拟上学周期间限制睡眠对昼夜节律、睡眠阶段和白天功能的影响。在模拟的周末恢复期间，检查了几天内和几天内的变化。研究对象为健康中学生12人，男6人，年龄15~17岁，平均16.1岁，标准差(SD)=0.9。两晚10h(21：30~07：30h)后，卧床时间限制为5h，连续5晚(02：30~07：30h)，然后恢复到10h，连续2晚(21：30~07：30)。在第一个和最后一个睡眠限制的夜晚，在昏暗的灯光下收集唾液，以测量褪黑素的开始阶段。睡眠监测采用多导睡眠记录仪，清醒状态下每隔3小时进行精神运动警戒任务(PVT)和Karolinska嗜睡量表测试。褪黑素测定的平均时相延迟为3h(SD=50min)。与基线相比，限制睡眠期间的睡眠包括较少的阶段1和阶段2以及快速眼动(REM)和较大比例的阶段4。PVT下降在睡眠限制期间显著增加，在恢复期间没有恢复到基线水平。主观嗜睡感在禁食期间表现出类似的模式，但在恢复期间恢复到基线水平。结果表明，睡眠限制会对青少年的持续注意力产生负面影响，特别是在清晨，周末的恢复性睡眠不足以恢复表现。嗜睡等级和表现之间的差异可能表明缺乏对这种残余损害的感知。
This laboratory study investigated the impact of restricted sleep during a simulated school week on circadian phase, sleep stages and daytime functioning. Changes were examined across and within days and during a simulated weekend recovery. Participants were 12 healthy secondary school students (six male) aged 15-17 years [mean = 16.1 years, standard deviation (SD) = 0.9]. After 2 nights with 10 h (21: 30-07: 30 hours), time in bed was restricted to 5 h for 5 nights (02: 30-07: 30 hours), then returned to 10 h time in bed for 2 nights (21: 30-07: 30 hours). Saliva was collected in dim light on the first and last sleep restriction nights to measure melatonin onset phase. Sleep was recorded polysomnographically, and the Psychomotor Vigilance Task (PVT) and Karolinska Sleepiness Scale were undertaken 3-hourly while awake. Average phase delaymeasured by melatonin was 3 h (SD = 50 min). Compared to baseline, sleep during the restriction period contained a smaller percentage of Stages 1 and 2 and rapid eye movement (REM) and a greater percentage of Stage 4. PVT lapses increased significantly during sleep restriction and did not return to baseline levels during recovery. Subjective sleepiness showed a similar pattern during restriction, but returned to baseline levels during recovery. Results suggest that sustained attention in adolescents is affected negatively by sleep restriction, particularly in the early morning, and that a weekend of recovery sleep is insufficient to restore performance. The discrepancy between sleepiness ratings and performance may indicate a lack of perception of this residual impairment.