The Immunobiology of Interleukin-35 and Its Regulation and Gene Expression
The Immunobiology of Interleukin-35 and Its Regulation and Gene Expression
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IL-35的免疫生物学及其调控和基因表达
DOI：
10.1007/978-94-024-0921-5_10
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Ma, Xiaojing
中科院分区：
文献类型：
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作者：
Song, Mei;Ma, Xiaojing
白细胞介素-35（IL-35）是IL-12家族的最新成员，由IL-12 p35亚基和IL-27 β亚基Epstein巴尔病毒诱导的3（EBI 3）组成。自发现以来，IL-35已显示出与IL-12家族的其他成员不同的免疫抑制活性。IL-35的独特之处还在于它主要由调节性T细胞（T-CTL）而不是抗原呈递细胞（APC）表达。IL-35可以直接抑制效应T细胞的增殖和功能，并抑制Th 17细胞的分化。它还能够通过产生产生IL-35的诱导型T细胞（iTr 35）的有效群体来扩大调节反应以促进对感染的耐受性。随着IL-35的新细胞来源如CD 8（+）T（+）、B-T细胞和致耐受性树突状细胞DC（tolDC）被鉴定，该细胞因子的更多免疫调节功能被探索。IL-35已被证明与一系列自身免疫性疾病和癌症模型相关。它似乎是一种很有前途诊断生物标记物。进一步了解IL-35的表达和调控机制将有助于开发新的免疫疗法。
Interleukin-35 (IL-35) is the latest addition to the IL-12 family of heterodimeric cytokines, consisting of IL-12 p35 subunit and IL-27 beta subunit Epstein Barr virus induced 3 (EBI3). Since its discovery, IL-35 has been shown to exhibit immunosuppressive activities which are distinct from other members of IL-12 family. IL-35 is also unique in that it is expressed primarily by regulatory T-cells (T-regs) rather than by antigen-presenting cells (APCs). IL-35 can directly suppress effector T-cell proliferation and function and inhibit the differentiation of Th17 cells. It is also able to expand regulatory responses to promote tolerance to infections by generating a potent population of IL-35-producing inducible T-regs (iTr35). As the new cellular sources of IL-35 such as CD8(+)T(regs), B-regs, and tolerogenic dendritic cells DCs (tolDCs) are identified, more immunoregulatory functions of this cytokine are explored. IL-35 has been shown to be associated with a range of autoimmune diseases and cancer models. It appears to be a promising diagnostic bioinarker. A greater understanding of the expression and regulatory mechanisms of IL-35 will be beneficial to the development of novel immune therapies.