CD4+ T cell responses to cytomegalovirus in early life:: A prospective birth cohort study
CD4+ T cell responses to cytomegalovirus in early life:: A prospective birth cohort study
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DOI：
10.1086/527418
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发表时间：
2008-03-01
影响因子：
6.4
通讯作者：
Marchant, Arnaud
中科院分区：
文献类型：
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作者：
Miles, David J. C.;van der Sande, Marianne;Marchant, Arnaud
我们比较了婴儿与慢性感染成人和4-5岁儿童的巨细胞病毒(CMV)特异性干扰素-γ(干扰素-γ)、白介素2(IL-2)和CD154(+)T细胞的反应。尽管干扰素-γ+CD154的共表达多于干扰素-γ+IL-2或IL-2+CD154的共表达，但应答的大小相似。反应在婴儿期保持不变，尽管产生干扰素-伽马的细胞比例从婴儿期到成年期增加。婴儿中的大多数反应细胞是未分化的(即CD27(+)CD28(+))，尽管产生干扰素的细胞不成比例地是CD27(-)。到确诊后12个月，病毒血症很少被检测到，这表明尽管CMV特异性的CD4(+)T细胞反应发展缓慢，CMV仍得到了控制。
We compared cytomegalovirus (CMV)-specific interferon-gamma (IFN-gamma), interleukin 2 (IL-2), and CD154 CD4(+) T cell responses of infants to those from chronically infected adults and from children aged 4-5 years. Magnitudes of the responses were similar, although coexpression of IFN-gamma plus CD154 occurred more than coexpression of IFN-gamma plus IL-2 or IL-2 plus CD154. Responses remained constant during infancy, although the proportion of IFN-gamma-producing cells increased from infancy to adulthood. Most responding cells in infants were undifferentiated (i.e., CD27(+)CD28(+)), although IFN-gamma-producing cells were disproportionately CD27(-). By 12 months after diagnosis, viremia was rarely detectable, indicating that CMV was controlled despite the slow development of CMV-specific CD4(+) T cell responses.