Trends in serum lipids and lipoproteins of adults, 1960-2002
Trends in serum lipids and lipoproteins of adults, 1960-2002
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DOI：
10.1001/jama.294.14.1773
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发表时间：
2005-10-12
影响因子：
120.7
通讯作者：
Johnson, CL
中科院分区：
文献类型：
--
作者：
Carroll, MD;Lacher, DA;Johnson, CL
背景血清总胆固醇和低密度脂蛋白胆固醇在动脉粥样硬化及其临床后遗症中起重要作用。以前对国家健康和营养调查（NHANES）数据的分析表明，美国成年人的总胆固醇平均水平从1960-1962年到1988-1994年有所下降，和低密度脂蛋白胆固醇的平均水平（1976年开始）在1976-1980年和1988- 1994年之间有所下降。目的研究1960 - 2002年美国成年人血脂水平的变化趋势，特别关注自1988-1994年NHANES调查以来的变化。设计、设置和参与者在1960-1962年、1971-1974年、1976-1980年、1988-1994年期间，主要结果测量平均血清总胆固醇、LDL胆固醇、高密度脂蛋白（HDL）胆固醇和几何平均血清甘油三酯水平，以及血清总胆固醇水平至少为240 mg/dL的成人百分比结果1988-1994年和1999 ~ 2002年，20岁或以上成年人的血清总胆固醇水平从206 mg/dL（5.34 mmol/L）至203 mg/dL（5.26 mmol/L）（P= 0.009）和LDL胆固醇水平从129 mg/dL下降（3.34 mmol/L）降至123 mg/dL（3.19 mmol/L）（P= 6.22 mmol/L），从1988-1994年期间的20%降至1999-2002年期间的17%（P= 6.22 mmol/L），达到了《2010年健康人群》的目标。使用降脂药物的成年人比例增加，特别是在老年人群中，可能导致观察到的总胆固醇和LDL胆固醇水平下降。美国人群中肥胖患病率增加可能导致平均血清甘油三酯水平升高。
Context Serum total and low-density lipoprotein (LDL) cholesterol contribute significantly to atherosclerosis and its clinical sequelae. Previous analyses of data from the National Health and Nutrition Examination Surveys (NHANES) showed that mean levels of total cholesterol of US adults had declined from 1960-1962 to 1988-1994, and mean levels of LDL cholesterol (available beginning in 1976) had declined between 1976-1980 and 1988-1994.Objective To examine trends in serum lipid levels among US adults between 1960 and 2002, with a particular focus on changes since the 1988-1994 NHANES survey.Design, Setting, and Participants Blood lipid measurements taken from 6098 to 15 719 adults who were examined in 5 distinct cross-sectional surveys of the US population during 1960-1962, 1971-1974, 1976-1980, 1988-1994, and 1999-2002.Main Outcome Measures Mean serum total cholesterol, LDL cholesterol, high-density lipoprotein (HDL) cholesterol, and geometric mean serum triglyceride levels, and the percentage of adults with a serum total cholesterol level of at least 240 mg/dL (>= 6.22 mmol/L).Results Between 1988-1994 and 1999-2002, total serum cholesterol level of adults aged 20 years or older decreased from 206 mg/dL (5.34 mmol/L) to 203 mg/dL (5.26 mmol/L) (P=.009) and LDL cholesterol levels decreased from 129 mg/dL (3.34 mmol/L) to 123 mg/dL (3.19 mmol/L) (P= 6.22 mmol/L) decreased from 20% during 1988-1994 to 17% during 1999-2002 (P= 6.22 mmol/L), an objective of Healthy People 2010, has been attained. The increase in the proportion of adults using lipid-lowering medication, particularly in older age groups, likely contributed to the decreases in total and LDL cholesterol levels observed. The increased prevalence of obesity in the US population may have contributed to the increase in mean serum triglyceride levels.